2BWG

Structure of human guanosine monophosphate reductase GMPR1 in complex with GMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	GMP REDUCTASE I	polymer	367	39991.5	4	UniProt (P36959) Pfam (PF00478)	HOMO SAPIENS	GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE 1, GUANOSINE MONOPHOSPHATE REDUCTASE 1
2	E, G, I, K (A, B, C, D)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
3	F, H, J, L (A, B, C, D)	GUANOSINE-5'-MONOPHOSPHATE	non-polymer		363.2	4	Chemie (5GP)
4	M, N, O, P (A, B, C, D)	water	water		18.0	193	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 345 (UniProt: P36959)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag
Ile 256	Phe 256	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	159966.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1609.3
All*	Total formula weight	161575.4

*Water molecules are not included.