2BUJ

Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SERINE/THREONINE-PROTEIN KINASE 16	polymer	317	36306.5	2	UniProt (O75716) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	HUMAN SERINE THREONINE KINASE 16, PROTEIN KINASE PKL12, MYRISTOYLATED AND PALMITOYLATED SERINE/THREONINE KINASE, MPSK, TGF-BETA STIMULATED FACTOR 1, TSF-1, HPSK
2	C, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
3	D, E, G, H (A, B)	STAUROSPORINE	non-polymer		466.5	4	Chemie (STU)
4	I, J (A, B)	water	water		18.0	76	Chemie (HOH)

Sequence modifications

A, B: -10 - 12 (PDB: 2BUJ)
A, B: 306 - 306 (PDB: 2BUJ)
A, B: 13 - 305 (UniProt: O75716)

PDB	External Database	Details
His 19	Arg 18	engineered mutation
Trp 266	Arg 265	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72613.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1937.0
All*	Total formula weight	74550.0

*Water molecules are not included.