2BEC

Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Calcineurin B homologous protein 2	polymer	202	23316.3	1	UniProt (O43745) Pfam (PF13202) Pfam (PF00036) In PDB	Homo sapiens (human)	Hepatocellular carcinoma-associated antigen 520, Human Calcineurin Homologous Protein CHP2
2	B	Sodium/hydrogen exchanger 1	polymer	43	5015.7	1	UniProt (P19634) In PDB	Homo sapiens (human)	Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1, Na(+)/H(+) antiporter, amiloride-sensitive, APNH
3	A	YTTRIUM (III) ION	non-polymer		88.9	2	Chemie (YT3)

Sequence modifications

A: 1 - 196 (UniProt: O43745)

PDB	External Database	Details
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28332.0
Non-Polymers*	Number of molecules	2
	Total formula weight	177.8
All*	Total formula weight	28509.8

*Water molecules are not included.