2BEC
Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0010922 | biological_process | positive regulation of phosphatase activity |
| A | 0015031 | biological_process | protein transport |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0042306 | biological_process | regulation of protein import into nucleus |
| A | 0042307 | biological_process | positive regulation of protein import into nucleus |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0070884 | biological_process | regulation of calcineurin-NFAT signaling cascade |
| A | 0070886 | biological_process | positive regulation of calcineurin-NFAT signaling cascade |
| A | 0071277 | biological_process | cellular response to calcium ion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE YT3 A 1201 |
| Chain | Residue |
| A | ASP165 |
| A | ASP167 |
| A | ASP169 |
| A | ALA171 |
| A | GLU176 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE YT3 A 1202 |
| Chain | Residue |
| A | LYS130 |
| A | GLU135 |
| A | ASP95 |
| A | ASP124 |
| A | ASP126 |
| A | ASP128 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DLDRDGKISrhEM |
| Chain | Residue | Details |
| A | ASP124-MET136 | |
| A | ASP165-PHE177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | Motif: {"description":"Nuclear export signal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q810D1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
