2BCK

Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	HLA class I histocompatibility antigen, A-24 alpha chain	polymer	294	33720.2	2	UniProt (P05534) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439)	Homo sapiens (human)	MHC class I antigen A*24, Aw-24, A-9, HLA-A*2402 Heavy Chain, alpha chain
2	B, E (B, E)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (human)	HLA-A*2402 Light Chain
3	C, F (C, F)	Telomerase reverse transcriptase	polymer	9	1028.2	2	UniProt (O14746)		Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, TP2
4	G, H, I, K, L... (A, B, D, E)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
5	J, M, O, R (A, B, D, E)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	S, T, U, V, W (A, B, D, E, F)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, D: 1 - 276 (UniProt: P05534)

PDB	External Database	Details
Gly 277	-	cloning artifact
Ser 278	-	cloning artifact
Gly 279	-	cloning artifact
Gly 280	-	cloning artifact
Gly 281	-	cloning artifact
Leu 282	-	cloning artifact
Asn 283	-	cloning artifact
Asp 284	-	cloning artifact
Ile 285	-	cloning artifact
Phe 286	-	cloning artifact
Glu 287	-	cloning artifact
Ala 288	-	cloning artifact
Gln 289	-	cloning artifact
Lys 290	-	cloning artifact
Ile 291	-	cloning artifact
Glu 292	-	cloning artifact
Trp 293	-	cloning artifact
His 294	-	cloning artifact

B, E: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	93255.6
Non-Polymers*	Number of molecules	12
	Total formula weight	1136.9
All*	Total formula weight	94392.5

*Water molecules are not included.