2BC4

Crystal structure of HLA-DM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	HLA class II histocompatibility antigen, DM alpha chain	polymer	211	23992.8	2	GenBank (18765715) Pfam (PF00993) Pfam (PF07654) UniProt (by SIFTS) (P28067) In PDB	Homo sapiens (human)	MHC class II antigen DMA
2	B, D	HLA class II histocompatibility antigen, DM beta chain	polymer	211	23580.7	2	GenBank (4504399) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P28068) In PDB	Homo sapiens (human)	MHC class II antigen DMB
3	E, F	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G41765YL)
4	A, B, C, D	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
5		water	water		18.0	420	Chemie (HOH)

Sequence modifications

A, C: 1 - 203 (GenBank: 18765715)

PDB	External Database	Details
Asp 204	-	expression tag
Tyr 205	-	expression tag
Lys 206	-	expression tag
Asp 207	-	expression tag
Asp 208	-	expression tag
Asp 209	-	expression tag
Asp 210	-	expression tag
Lys 211	-	expression tag

B, D: 1 - 200 (GenBank: 4504399)

PDB	External Database	Details
Lys 201	-	expression tag
Pro 202	-	expression tag
Pro 203	-	expression tag
Thr 204	-	expression tag
Pro 205	-	expression tag
Pro 206	-	expression tag
Pro 207	-	expression tag
Glu 208	-	expression tag
Pro 209	-	expression tag
Glu 210	-	expression tag
Thr 211	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	95147.1
Branched	Number of molecules	2
	Total formula weight	1497.4
Non-Polymers*	Number of molecules	4
	Total formula weight	141.8
All*	Total formula weight	96786.2

*Water molecules are not included.