2BBR

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Viral CASP8 and FADD-like apoptosis regulator	polymer	195	22170.6	1	UniProt (Q98325) Pfam (PF01335) In PDB	Molluscum contagiosum virus subtype 1	v-CFLAR, Viral FLICE-inhibitory protein, v-FLIP
2	A	AZIDE ION	non-polymer		42.0	1	Chemie (AZI)
3		water	water		18.0	319	Chemie (HOH)

Sequence modifications

A: 1 - 187 (UniProt: Q98325)

PDB	External Database	Details
Leu 188	-	expression tag
Glu 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22170.6
Non-Polymers*	Number of molecules	1
	Total formula weight	42.0
All*	Total formula weight	22212.6

*Water molecules are not included.