2B8W

Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Interferon-induced guanylate-binding protein 1	polymer	328	37078.4	2	UniProt (P32455) Pfam (PF02263) In PDB	Homo sapiens (human)	GTP-binding protein 1, Guanine nucleotide-binding protein 1, HuGBP-1
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	TETRAFLUOROALUMINATE ION	non-polymer		103.0	2	Chemie (ALF)
4	A, B	GUANOSINE-5'-MONOPHOSPHATE	non-polymer		363.2	2	Chemie (5GP)
5		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A, B: 1 - 317 (UniProt: P32455)

PDB	External Database	Details
Met -10	-	cloning artifact
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Met -3	-	cloning artifact
Arg -2	-	cloning artifact
Gly -1	-	cloning artifact
Ser 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74156.9
Non-Polymers*	Number of molecules	6
	Total formula weight	981.0
All*	Total formula weight	75137.9

*Water molecules are not included.