2B8W
Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 595 |
| Chain | Residue |
| A | SER52 |
| A | THR75 |
| A | 5GP593 |
| A | ALF594 |
| A | HOH633 |
| A | HOH647 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 595 |
| Chain | Residue |
| B | ALF594 |
| B | HOH649 |
| B | HOH671 |
| B | SER52 |
| B | THR75 |
| B | 5GP593 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ALF A 594 |
| Chain | Residue |
| A | TYR47 |
| A | ARG48 |
| A | LYS51 |
| A | SER73 |
| A | HIS74 |
| A | THR75 |
| A | THR98 |
| A | GLY100 |
| A | 5GP593 |
| A | MG595 |
| A | HOH602 |
| A | HOH633 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ALF B 594 |
| Chain | Residue |
| B | TYR47 |
| B | ARG48 |
| B | LYS51 |
| B | SER73 |
| B | HIS74 |
| B | THR75 |
| B | GLY100 |
| B | 5GP593 |
| B | MG595 |
| B | HOH599 |
| B | HOH649 |
| B | HOH671 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 5GP A 593 |
| Chain | Residue |
| A | ARG48 |
| A | THR49 |
| A | GLY50 |
| A | LYS51 |
| A | SER52 |
| A | TYR53 |
| A | GLY68 |
| A | ARG183 |
| A | ASP184 |
| A | PRO241 |
| A | LEU247 |
| A | LEU250 |
| A | ALF594 |
| A | MG595 |
| A | HOH603 |
| A | HOH619 |
| B | LEU187 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 5GP B 593 |
| Chain | Residue |
| B | ARG48 |
| B | THR49 |
| B | GLY50 |
| B | LYS51 |
| B | SER52 |
| B | TYR53 |
| B | GLY68 |
| B | ARG183 |
| B | ASP184 |
| B | PRO241 |
| B | LEU247 |
| B | LEU250 |
| B | ALF594 |
| B | MG595 |
| B | HOH623 |
| B | HOH670 |
| B | HOH671 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10676968, ECO:0000269|PubMed:10970849, ECO:0000269|PubMed:16511497, ECO:0007744|PDB:1F5N, ECO:0007744|PDB:2B8W, ECO:0007744|PDB:2B92, ECO:0007744|PDB:2D4H |
| Chain | Residue | Details |
| A | GLY45 | |
| A | LEU67 | |
| B | GLY45 | |
| B | LEU67 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10676968, ECO:0000269|PubMed:10970849, ECO:0007744|PDB:1F5N |
| Chain | Residue | Details |
| A | ASP97 | |
| B | ASP97 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PIM1 => ECO:0000269|PubMed:37797010 |
| Chain | Residue | Details |
| A | SER156 | |
| B | SER156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:29144452 |
| Chain | Residue | Details |
| A | LYS207 | |
| A | LYS209 | |
| A | LYS210 | |
| B | LYS207 | |
| B | LYS209 | |
| B | LYS210 |
