2B4T
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom resolution reveals intriguing extra electron density in the active site
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | O, P, Q, R | glyceraldehyde-3-phosphate dehydrogenase | polymer | 345 | 37644.3 | 4 | UniProt (Q8T6B1) Pfam (PF00044) Pfam (PF02800) In PDB | Plasmodium falciparum (malaria parasite P. falciparum) | |
2 | O, P, Q, R | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
3 | O, P, R | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE | non-polymer | 203.2 | 3 | Chemie (AES) | |||
4 | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
O, P, Q, R: 1 - 337 (UniProt: Q8T6B1)
PDB | External Database | Details |
---|---|---|
Met -7 | - | cloning artifact |
Ala -6 | - | cloning artifact |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ala 3 | Val 3 | engineered mutation |
Thr 336 | Asn 336 | engineered mutation |
Ser 337 | Asn 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 150577.1 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3263.4 | |
All* | Total formula weight | 153840.5 |