2B4R
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom Resolution reveals intriguing extra electron density in the active site
Replaces: 1ZYAEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (O, P, Q, R) | glyceraldehyde-3-phosphate dehydrogenase | polymer | 345 | 37644.3 | 4 | UniProt (Q8T6B1) Pfam (PF00044) Pfam (PF02800) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | E, H, K, L (O, P, Q, R) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
| 3 | F, I, M (O, P, R) | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE | non-polymer | 203.2 | 3 | Chemie (AES) | |||
| 4 | G, J, N, O (O, P, R) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | P, Q, R, S (O, P, Q, R) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
O, P, Q, R: 1 - 337 (UniProt: Q8T6B1)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | cloning artifact |
| Ala -6 | - | cloning artifact |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 3 | Val 3 | engineered mutation |
| Thr 336 | Asn 336 | engineered mutation |
| Ser 337 | Asn 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150577.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3631.8 | |
| All* | Total formula weight | 154208.8 |
