2B4R

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom Resolution reveals intriguing extra electron density in the active site

Replaces:  1ZYA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	O, P, Q, R	glyceraldehyde-3-phosphate dehydrogenase	polymer	345	37644.3	4	UniProt (Q8T6B1) Pfam (PF00044) Pfam (PF02800) In PDB	Plasmodium falciparum (malaria parasite P. falciparum)
2	O, P, Q, R	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
3	O, P, R	4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE	non-polymer		203.2	3	Chemie (AES)
4	O, P, R	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5		water	water		18.0	257	Chemie (HOH)

Sequence modifications

O, P, Q, R: 1 - 337 (UniProt: Q8T6B1)

PDB	External Database	Details
Met -7	-	cloning artifact
Ala -6	-	cloning artifact
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ala 3	Val 3	engineered mutation
Thr 336	Asn 336	engineered mutation
Ser 337	Asn 337	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	150577.1
Non-Polymers*	Number of molecules	11
	Total formula weight	3631.8
All*	Total formula weight	154208.8

*Water molecules are not included.