2B4R

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 Angstrom Resolution reveals intriguing extra electron density in the active site

Replaces:  1ZYA

Functional Information from GO Data

Chain	GOid	namespace	contents
O	0000166	molecular_function	nucleotide binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0005829	cellular_component	cytosol
O	0006006	biological_process	glucose metabolic process
O	0006096	biological_process	glycolytic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0000166	molecular_function	nucleotide binding
P	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P	0005829	cellular_component	cytosol
P	0006006	biological_process	glucose metabolic process
P	0006096	biological_process	glycolytic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0000166	molecular_function	nucleotide binding
Q	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Q	0005829	cellular_component	cytosol
Q	0006006	biological_process	glucose metabolic process
Q	0006096	biological_process	glycolytic process
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0000166	molecular_function	nucleotide binding
R	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
R	0005829	cellular_component	cytosol
R	0006006	biological_process	glucose metabolic process
R	0006096	biological_process	glycolytic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD Q 501

Chain	Residue
P	HOH767
Q	SER98
Q	THR99
Q	GLY100
Q	PHE102
Q	SER122
Q	ALA123
Q	CYS153
Q	THR183
Q	ALA184
Q	ASN319
Q	GLY10
Q	TYR323
Q	HOH513
Q	HOH522
Q	HOH523
Q	HOH549
Q	HOH550
Q	PHE11
Q	GLY12
Q	ARG13
Q	ILE14
Q	ASP35
Q	PRO36
Q	PHE37

---

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD P 701

Chain	Residue
P	ASN9
P	GLY10
P	GLY12
P	ARG13
P	ILE14
P	ASN34
P	ASP35
P	PRO36
P	PHE37
P	LYS80
P	SER98
P	THR99
P	GLY100
P	SER122
P	ALA123
P	CYS153
P	ALA184
P	ASN319
P	TYR323
P	AES602
P	HOH707
P	HOH711
P	HOH720
P	HOH727
P	HOH732
P	HOH740
P	HOH754

---

site_id	AC3
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD O 801

Chain	Residue
O	ASN9
O	GLY10
O	PHE11
O	GLY12
O	ARG13
O	ILE14
O	ASN34
O	ASP35
O	PRO36
O	PHE37
O	MET38
O	GLU79
O	LYS80
O	SER98
O	THR99
O	GLY100
O	SER122
O	ALA123
O	CYS153
O	ALA184
O	ASN319
O	TYR323
O	AES601
O	HOH812
O	HOH829
O	HOH842
O	HOH847
O	HOH853
R	HOH963

---

site_id	AC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD R 901

Chain	Residue
R	ASN319
R	TYR323
R	AES603
R	HOH904
R	HOH907
R	HOH910
R	HOH918
R	HOH923
R	HOH939
R	HOH941
R	HOH942
R	ASN9
R	GLY10
R	GLY12
R	ARG13
R	ILE14
R	ASN34
R	ASP35
R	PRO36
R	PHE37
R	GLU79
R	LYS80
R	SER98
R	THR99
R	GLY100
R	PHE102
R	SER122
R	ALA123
R	ALA184

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AES O 601

Chain	Residue
O	THR183
O	ASN185
O	NAD801

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE AES P 602

Chain	Residue
P	THR183
P	ASN185
P	ARG237
P	NAD701

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AES R 603

Chain	Residue
R	THR183
R	ASN185
R	NAD901

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL R 503

Chain	Residue
Q	GLY196
Q	LYS197
Q	ASP198
Q	TRP199
R	GLU283

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL P 703

Chain	Residue
O	GLU283
P	GLY196
P	ASP198
P	TRP199

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL O 804

Chain	Residue
O	ASP292
O	ASN293
O	ARG294
R	GLU71

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL R 903

Chain	Residue
Q	GLU283
R	ASP198
R	TRP199

---

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
O	ALA151-LEU158

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FPCEVTH

Chain	Residue	Details
O	PHE56-HIS62

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