2AZ5
Crystal Structure of TNF-alpha with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form] | polymer | 148 | 16410.6 | 4 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (human) | |
| 2 | E, F (A, C) | 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE | non-polymer | 547.6 | 2 | Chemie (307) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65642.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1095.2 | |
| All* | Total formula weight | 66737.6 |
