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2AZ5

Crystal Structure of TNF-alpha with a small molecule inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 307 A 1
ChainResidue
ALEU57
BLEU120
BGLY121
BTYR151
ASER60
ATYR119
ALEU120
AGLY121
AGLY122
ATYR151
BTYR59
BTYR119

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 307 C 2
ChainResidue
CLEU57
CSER60
CTYR119
CLEU120
CGLY121
CGLY122
CTYR151
DTYR59
DSER60
DTYR119
DLEU120
DGLY121

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

227344

PDB entries from 2024-11-13

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