2AOT
Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histamine N-methyltransferase | polymer | 292 | 33365.0 | 1 | UniProt (P50135) Pfam (PF13489) | Homo sapiens (human) | HMT |
| 2 | B (B) | Histamine N-methyltransferase | polymer | 292 | 33365.0 | 1 | UniProt (P50135) Pfam (PF13489) | Homo sapiens (human) | |
| 3 | C, E (A, B) | N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE | non-polymer | 255.4 | 2 | Chemie (2PM) | |||
| 4 | D, F (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 337 | Chemie (HOH) |
Sequence modifications
A: 1 - 292 (UniProt: P50135)
B: 1 - 292 (UniProt: P50135)
| PDB | External Database | Details |
|---|---|---|
| Cys 82 | Cys 82 | modified residue |
| Cso 217 | Cys 217 | modified residue |
| Cso 248 | Cys 248 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Cso 82 | Cys 82 | modified residue |
| Cys 217 | Cys 217 | modified residue |
| Cso 248 | Cys 248 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66730.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1279.5 | |
| All* | Total formula weight | 68009.6 |
