2AOT

Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001692	biological_process	histamine metabolic process
A	0001695	biological_process	histamine catabolic process
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006548	biological_process	L-histidine catabolic process
A	0007268	biological_process	chemical synaptic transmission
A	0007585	biological_process	respiratory gaseous exchange by respiratory system
A	0008168	molecular_function	methyltransferase activity
A	0008170	molecular_function	N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0045202	cellular_component	synapse
A	0046539	molecular_function	histamine N-methyltransferase activity
A	0070062	cellular_component	extracellular exosome
B	0001692	biological_process	histamine metabolic process
B	0001695	biological_process	histamine catabolic process
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0006548	biological_process	L-histidine catabolic process
B	0007268	biological_process	chemical synaptic transmission
B	0007585	biological_process	respiratory gaseous exchange by respiratory system
B	0008168	molecular_function	methyltransferase activity
B	0008170	molecular_function	N-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
B	0045202	cellular_component	synapse
B	0046539	molecular_function	histamine N-methyltransferase activity
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2PM A 400

Chain	Residue
A	TYR146
A	TYR147
A	TRP179
A	TRP183
A	GLN197
A	TYR198
A	PHE243
A	HOH653

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2PM B 401

Chain	Residue
B	PHE22
B	TYR146
B	TYR147
B	TRP179
B	TRP183
B	CYS196
B	GLN197
B	TYR198
B	PHE243
B	GLU246
B	HOH685
B	TYR15

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 500

Chain	Residue
A	GLY60
A	GLY62
A	ILE66
A	GLU89
A	PRO90
A	GLN94
A	THR119
A	SER120
A	ILE142
A	GLN143
A	MET144
A	TYR147
A	HOH512
A	HOH513
A	HOH529
A	HOH559

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site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH B 501

Chain	Residue
B	HIS29
B	GLY60
B	GLY61
B	GLY62
B	GLU89
B	PRO90
B	GLN94
B	THR119
B	SER120
B	ILE142
B	GLN143
B	MET144
B	TYR147
B	HOH511
B	HOH515
B	HOH526
B	HOH533
B	HOH560
B	HOH567
B	HOH607

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

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