2AER
Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VII | polymer | 142 | 16359.8 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa |
| 2 | B (H) | Coagulation factor VII | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa |
| 3 | C (T) | Tissue factor | polymer | 206 | 23374.0 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | TF, Coagulation factor III, Thromboplastin, CD142 antigen |
| 4 | D (L) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 5 | E (L) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 6 | F, I, L (L) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 7 | G, H, J, K, M... (L, H) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 8 | O (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | P, Q (H) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 10 | R, S, U (H, T) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 11 | T (H) | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
| 12 | V, W, X (L, H, T) | water | water | 18.0 | 715 | Chemie (HOH) |
Sequence modifications
L: 1 - 142 (UniProt: P08709)
T: 6 - 210 (UniProt: P13726)
| PDB | External Database | Details |
|---|---|---|
| Cgu 6 | Glu 66 | modified residue |
| Cgu 7 | Glu 67 | modified residue |
| Cgu 14 | Glu 74 | modified residue |
| Cgu 16 | Glu 76 | modified residue |
| Cgu 19 | Glu 79 | modified residue |
| Cgu 20 | Glu 80 | modified residue |
| Cgu 25 | Glu 85 | modified residue |
| Cgu 26 | Glu 86 | modified residue |
| Cgu 29 | Glu 89 | modified residue |
| Cgu 35 | Glu 95 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Ala 5 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 67837.1 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1038.0 | |
| All* | Total formula weight | 68875.1 |
