2AEI
Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VII | polymer | 152 | 17487.1 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa |
| 2 | B (H) | Coagulation factor VII | polymer | 254 | 28103.3 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa |
| 3 | C (T) | Tissue factor | polymer | 211 | 23820.4 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | TF, Coagulation factor III, Thromboplastin, CD142 antigen |
| 4 | D, E, F, G, H... (L, H) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 5 | L (H) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 6 | M (H) | 2-({6-{3-[AMINO(IMINO)METHYL]PHENOXY}-3,5-DIFLUORO-4-[(1-METHYL-3-PHENYLPROPYL)AMINO]-2-PYRIDINYL}OXY)BENZOIC ACID | non-polymer | 532.5 | 1 | Chemie (03R) | |||
| 7 | N, O, P (L, H, T) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
L: 1 - 152 (UniProt: P08709)
| PDB | External Database | Details |
|---|---|---|
| Cgu 6 | Glu 66 | modified residue |
| Cgu 7 | Glu 67 | modified residue |
| Cgu 14 | Glu 74 | modified residue |
| Cgu 16 | Glu 76 | modified residue |
| Cgu 19 | Glu 79 | modified residue |
| Cgu 20 | Glu 80 | modified residue |
| Cgu 25 | Glu 85 | modified residue |
| Cgu 26 | Glu 86 | modified residue |
| Cgu 29 | Glu 89 | modified residue |
| Cgu 35 | Glu 95 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69410.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 990.2 | |
| All* | Total formula weight | 70400.9 |
