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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2AEI

Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
H0004252molecular_functionserine-type endopeptidase activity
H0006508biological_processproteolysis
L0005509molecular_functioncalcium ion binding
L0005576cellular_componentextracellular region
T0007596biological_processblood coagulation
T0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA L 501
ChainResidue
LCGU25
LCGU29
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA L 502
ChainResidue
LCGU7
LCGU25
LCGU26
LCGU29
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA L 503
ChainResidue
LCGU29
LCA504
LCGU7
LCGU16
LCGU26
site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CA L 504
ChainResidue
LALA1
LASN2
LCGU6
LCGU7
LCGU16
LCGU26
LCA503
LCA505
site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA L 505
ChainResidue
LALA1
LCGU6
LCGU16
LCGU20
LCA504
site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA L 506
ChainResidue
LCGU19
LCGU20
site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA L 509
ChainResidue
LASP46
LGLY47
LGLN49
LASP63
LGLN64
site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA H 510
ChainResidue
HGLU70
HASP72
HGLU75
HGLU80
HHOH632
site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CAC H 511
ChainResidue
HCYS168
HSER170
HGLN217
HGLY223
HHIS224
HPHE225
site_idBC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 03R H 500
ChainResidue
HHIS57
HTHR98
HTHR99
HASP189
HSER190
HCYS191
HLYS192
HGLY193
HSER195
HSER214
HTRP215
HGLY216
HGLN217
HGLY219
HCYS220
Functional Information from PROSITE/UniProt
site_idPS00010
Number of Residues12
DetailsASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDqlqsYiCfC
ChainResidueDetails
LCYS61-CYS72
site_idPS00011
Number of Residues26
DetailsGLA_1 Vitamin K-dependent carboxylation domain. EckEEqCsfeearEifkdaertkl.FW
ChainResidueDetails
LCGU16-TRP41
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CfClpAfeGRnC
ChainResidueDetails
LCYS70-CYS81
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
HVAL53-CYS58
site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA
ChainResidueDetails
HASP189-ALA200
site_idPS00621
Number of Residues18
DetailsTISSUE_FACTOR Tissue factor signature. WKsKCfyTtDTECDLTDE
ChainResidueDetails
TTRP45-GLU62
site_idPS01186
Number of Residues16
DetailsEGF_2 EGF-like domain signature 2. CrCheGYslladgvsC
ChainResidueDetails
LCYS112-CYS127
site_idPS01187
Number of Residues25
DetailsEGF_CA Calcium-binding EGF-like domain signature. DgDQCassp..........Cqnggs..CkDqlqsYiC
ChainResidueDetails
LASP46-CYS70
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsDomain: {"description":"EGF-like 1; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Important for S-112 for O-xylosylation"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"4-carboxyglutamate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00463","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3486420","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"(3R)-3-hydroxyaspartate","evidences":[{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (Xyl...) serine; alternate","evidences":[{"source":"PubMed","id":"1904059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2129367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21949356","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2511201","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (Fuc) serine","featureId":"CAR_000180","evidences":[{"source":"PubMed","id":"1904059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9023546","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues239
DetailsDomain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsActive site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsMotif: {"description":"WKS motif"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HASP102
HHIS57
site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HSER195
HGLY196
site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HSER195
HGLY193
site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HASP102
HSER195
HHIS57
site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HASP102
HSER195
HHIS57
HGLY196
site_idCSA6
Number of Residues4
DetailsAnnotated By Reference To The Literature 1a0j
ChainResidueDetails
HASP102
HSER195
HGLY193
HHIS57

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PDB entries from 2025-12-24

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