English 日本語简体中文繁體中文 한국어

✖

Menu

RCSB PDB PDBe BMRB Adv. Search Search help

Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2AEI

Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
L	0005509	molecular_function	calcium ion binding
L	0005576	cellular_component	extracellular region
T	0007596	biological_process	blood coagulation
T	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA L 501

Chain	Residue
L	CGU25
L	CGU29

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA L 502

Chain	Residue
L	CGU7
L	CGU25
L	CGU26
L	CGU29

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 503

Chain	Residue
L	CGU29
L	CA504
L	CGU7
L	CGU16
L	CGU26

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA L 504

Chain	Residue
L	ALA1
L	ASN2
L	CGU6
L	CGU7
L	CGU16
L	CGU26
L	CA503
L	CA505

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 505

Chain	Residue
L	ALA1
L	CGU6
L	CGU16
L	CGU20
L	CA504

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA L 506

Chain	Residue
L	CGU19
L	CGU20

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 509

Chain	Residue
L	ASP46
L	GLY47
L	GLN49
L	ASP63
L	GLN64

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 510

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH632

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CAC H 511

Chain	Residue
H	CYS168
H	SER170
H	GLN217
H	GLY223
H	HIS224
H	PHE225

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 03R H 500

Chain	Residue
H	HIS57
H	THR98
H	THR99
H	ASP189
H	SER190
H	CYS191
H	LYS192
H	GLY193
H	SER195
H	SER214
H	TRP215
H	GLY216
H	GLN217
H	GLY219
H	CYS220

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDqlqsYiCfC

Chain	Residue	Details
L	CYS61-CYS72

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EckEEqCsfeearEifkdaertkl.FW

Chain	Residue	Details
L	CGU16-TRP41

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CfClpAfeGRnC

Chain	Residue	Details
L	CYS70-CYS81

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

site_id	PS00621
Number of Residues	18
Details	TISSUE_FACTOR Tissue factor signature. WKsKCfyTtDTECDLTDE

Chain	Residue	Details
T	TRP45-GLU62

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCassp..........Cqnggs..CkDqlqsYiC

Chain	Residue	Details
L	ASP46-CYS70

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
T	ASN124
T	ASN137
H	SER195

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
H	ASP189

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19167329, ECO:0000269\|PubMed:3264725

Chain	Residue	Details
H	ASN175
L	CGU7
L	CGU14
L	CGU16
L	CGU20
L	CGU25
L	CGU26
L	CGU29
L	CGU35

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 4-carboxyglutamate => ECO:0000255\|PROSITE-ProRule:PRU00463, ECO:0000269\|PubMed:3264725

Chain	Residue	Details
L	CGU19

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000269\|PubMed:3264725

Chain	Residue	Details
L	ASP63

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: O-linked (Xyl...) serine; alternate => ECO:0000269\|PubMed:1904059, ECO:0000269\|PubMed:2129367, ECO:0000269\|PubMed:21949356, ECO:0000269\|PubMed:2511201

Chain	Residue	Details
L	SER52

site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: O-linked (Fuc) serine => ECO:0000269\|PubMed:1904059, ECO:0000269\|PubMed:9023546

Chain	Residue	Details
L	SER60

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19167329, ECO:0000269\|PubMed:3264725

Chain	Residue	Details
L	ASN145

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY196

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY193

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57
H	GLY196

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	GLY193
H	HIS57

226707

PDB entries from 2024-10-30

PDB statistics

PDBj update info

Contact PDBj

numon