2ACX

Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	G protein-coupled receptor kinase 6	polymer	576	66010.7	2	UniProt (P43250) Pfam (PF00615) Pfam (PF00069) In PDB	Homo sapiens (human)	G protein-coupled receptor kinase GRK6
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A, B	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
5		water	water		18.0	37	Chemie (HOH)

Sequence modifications

A, B: 1 - 576 (UniProt: P43250)

PDB	External Database	Details
Asn 60	Gln 60	SEE REMARK 999
Asn 104	Gln 104	SEE REMARK 999
Ser 561	Cys 561	engineered mutation
Ser 562	Cys 562	engineered mutation
Ser 565	Cys 565	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	132021.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1250.9
All*	Total formula weight	133272.3

*Water molecules are not included.