2ABZ
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Carboxypeptidase A1 | polymer | 309 | 34721.8 | 2 | UniProt (P00730) Pfam (PF00246) | Bos taurus (cattle) | carboxypeptidase A, CPA, A/B metallocarboxypeptidase |
| 2 | C, D, E, F (C, D, E, F) | Metallocarboxypeptidase inhibitor | polymer | 67 | 7333.1 | 4 | UniProt (P81511) | Hirudo medicinalis (medicinal leech) | Leech carboxypeptidase inhibitor, LCI, inhibitor of A/B metallocarboxypeptidases |
| 3 | G, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, B: 1 - 309 (UniProt: P00730)
C, D, E, F: 2 - 67 (UniProt: P81511)
| PDB | External Database | Details |
|---|---|---|
| Ala 228 | Glu 338 | SEE REMARK 999 |
| Val 305 | Leu 415 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ala 19 | Cys 33 | engineered mutation |
| Ala 43 | Cys 57 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 98776.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 98906.8 |
