2A69

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, K, L	DNA-directed RNA polymerase alpha chain	polymer	315	35056.2	4	UniProt (Q9Z9H6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) UniProt (by SIFTS) (Q5SHR6) In PDB	Thermus thermophilus	RNAP alpha subunit, Transcriptase alpha chain, RNA polymerase alpha subunit
2	C, M	DNA-directed RNA polymerase beta chain	polymer	1119	125436.5	2	UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) In PDB	Thermus thermophilus	RNAP beta subunit, Transcriptase beta chain, RNA polymerase beta subunit
3	D, N	DNA-directed RNA polymerase beta' chain	polymer	1524	170997.4	2	UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB	Thermus thermophilus	RNAP beta' subunit, Transcriptase beta' chain, RNA polymerase beta' subunit
4	E, O	RNA polymerase omega chain	polymer	99	11521.2	2	GenBank (20160394) Pfam (PF01192) UniProt (by SIFTS) (Q8RQE7) In PDB	Thermus thermophilus
5	F, P	RNA polymerase sigma factor rpoD	polymer	423	48568.0	2	GenBank (46198472) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q5SKW1) In PDB	Thermus thermophilus
6	A, B, C, D, F...	MAGNESIUM ION	non-polymer		24.3	487	Chemie (MG)
7	M, C	RIFAPENTINE	non-polymer		877.0	2	Chemie (RPT)
8	D, N	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
9		water	water		18.0	6399	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	853271.0
Non-Polymers*	Number of molecules	493
	Total formula weight	13852.2
All*	Total formula weight	867123.2

*Water molecules are not included.