2A5D
Structural basis for the activation of cholera toxin by human ARF6-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADP-ribosylation factor 6 | polymer | 175 | 20110.2 | 1 | UniProt (P62330) Pfam (PF00025) | Homo sapiens (human) | |
| 2 | B (B) | Cholera enterotoxin, A chain | polymer | 193 | 21710.8 | 1 | UniProt (P01555) Pfam (PF01375) | Vibrio cholerae | NAD(+)--diphthamide ADP-ribosyltransferase, Cholera enterotoxin A subunit |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | E (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 6 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A: 2 - 175 (UniProt: P62330)
B: 1 - 192 (UniProt: P01555)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | cloning artifact |
| Asp 110 | Glu 128 | engineered mutation |
| Asp 112 | Glu 130 | engineered mutation |
| Ser 187 | Cys 205 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41820.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 662.6 | |
| All* | Total formula weight | 42483.5 |
