2A5D
Structural basis for the activation of cholera toxin by human ARF6-GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ADP-ribosylation factor 6 | polymer | 175 | 20110.2 | 1 | UniProt (P62330) Pfam (PF00025) | Homo sapiens (human) | |
| 2 | B (B) | Cholera enterotoxin, A chain | polymer | 193 | 21710.8 | 1 | UniProt (P01555) Pfam (PF01375) | Vibrio cholerae | NAD(+)--diphthamide ADP-ribosyltransferase, Cholera enterotoxin A subunit |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | E (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A: 2 - 175 (UniProt: P62330)
B: 1 - 192 (UniProt: P01555)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | cloning artifact |
| Asp 110 | Glu 128 | engineered mutation |
| Asp 112 | Glu 130 | engineered mutation |
| Ser 187 | Cys 205 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41820.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 662.6 | |
| All* | Total formula weight | 42483.5 |
