2A4O
Dual modes of modification of Hepatitis A virus 3C protease by a serine derived beta-lactone: selective crytstallization and high resolution structure of the His102 adduct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Probable protein P3C | polymer | 219 | 24119.8 | 1 | UniProt (P13901) | Human hepatitis A virus Hu/Northern Africa/MBB/1978 | 3C protease |
| 2 | B (A) | N-[(BENZYLOXY)CARBONYL]-L-ALANINE | non-polymer | 223.2 | 1 | Chemie (BBL) | |||
| 3 | C (A) | ACETYL GROUP | non-polymer | 44.1 | 1 | Chemie (ACE) | |||
| 4 | D (A) | VALINE | non-polymer | 117.1 | 1 | Chemie (VAL) | |||
| 5 | E (A) | PHENYLALANINE AMIDE | non-polymer | 164.2 | 1 | Chemie (NFA) | |||
| 6 | F (A) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 1 - 219 (UniProt: P13901)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Cys 1543 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24119.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 548.6 | |
| All* | Total formula weight | 24668.4 |
