2A2Z

Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Deoxycytidine kinase	polymer	248	29139.0	4	UniProt (P27707) Pfam (PF01712)	Homo sapiens (human)	dCK
2	E, L (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
3	F, I, M, P (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
4	G, J, N, Q (A, B, C, D)	2'-DEOXYCYTIDINE	non-polymer		227.2	4	Chemie (DCZ)
5	H, K, O, R (A, B, C, D)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	4	Chemie (UDP) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (57448939) PubChem (60098857) PubChem (1158) PubChem (6031) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) PubChem (3084486) PubChem (6101632) PubChem (6604175) PubChem (11811538) PubChem (12049241)
6	S, T, U, V (A, B, C, D)	water	water		18.0	67	Chemie (HOH)

Sequence modifications

A, B, C, D: 4 - 260 (UniProt: P27707)

PDB	External Database	Details
Gly -2	-	cloning artifact
Ser -1	-	cloning artifact
His 0	-	cloning artifact
-	Gln 65	deletion
-	Asp 66	deletion
-	Glu 67	deletion
-	Phe 68	deletion
-	Glu 69	deletion
-	Glu 70	deletion
-	Leu 71	deletion
-	Thr 72	deletion
-	Met 73	deletion
-	Ser 74	deletion
-	Gln 75	deletion
-	Lys 76	deletion
-	Asn 77	deletion
-	Gly 78	deletion
-	Gly 79	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	116556.0
Non-Polymers*	Number of molecules	14
	Total formula weight	2702.9
All*	Total formula weight	119258.9

*Water molecules are not included.