2A1A
PKR kinase domain-eIF2alpha Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Eukaryotic translation initiation factor 2 alpha subunit | polymer | 175 | 20553.8 | 1 | UniProt (P20459) Pfam (PF00575) Pfam (PF07541) In PDB | Saccharomyces cerevisiae (baker's yeast) | eIF-2- alpha |
| 2 | B | Interferon-induced, double-stranded RNA-activated protein kinase | polymer | 284 | 32799.6 | 1 | UniProt (P19525) Pfam (PF00069) In PDB | Homo sapiens (human) | Interferon-inducible RNA-dependent protein kinase, p68 kinase, P1/eIF-2A protein kinase |
| 3 | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A: 3 - 175 (UniProt: P20459)
B: 258 - 538 (UniProt: P19525)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | cloning artifact |
| Ser 2 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 255 | - | cloning artifact |
| Ala 256 | - | cloning artifact |
| His 257 | - | cloning artifact |
| - | Asp 338 | deletion |
| - | Asp 339 | deletion |
| - | Ser 340 | deletion |
| - | Leu 341 | deletion |
| - | Glu 342 | deletion |
| - | Ser 343 | deletion |
| - | Ser 344 | deletion |
| - | Asp 345 | deletion |
| - | Tyr 346 | deletion |
| - | Asp 347 | deletion |
| - | Pro 348 | deletion |
| - | Glu 349 | deletion |
| - | Asn 350 | deletion |
| Asn 412 | His 412 | engineered mutation |
| Tpo 446 | Thr 446 | modified residue |
| Ala 551 | Cys 551 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53353.3 | |
| All* | Total formula weight | 53353.3 |
