29HG
Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | F-box only protein 22 | polymer | 403 | 44562.3 | 1 | UniProt (Q8NEZ5) | Homo sapiens (human) | F-box protein FBX22p44 |
| 2 | B (B) | Histone-lysine N-methyltransferase NSD2 | polymer | 1365 | 152515.5 | 1 | UniProt (O96028) | Homo sapiens (human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
| 3 | C (C) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 4 | D (D) | Cullin-1 | polymer | 776 | 89800.4 | 1 | UniProt (Q13616) | Homo sapiens (human) | CUL-1 |
| 5 | E (E) | E3 ubiquitin-protein ligase RBX1 | polymer | 108 | 12290.0 | 1 | UniProt (P62877) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1 |
| 6 | F (B) | ~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide | non-polymer | 608.7 | 1 | Chemie (A1J20) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 317848.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 608.7 | |
| All* | Total formula weight | 318456.7 |
