28OQ
Protein Kinaze domain PAK1 complexed with NVS inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Serine/threonine-protein kinase PAK 1 | polymer | 297 | 33353.2 | 2 | UniProt (Q13153) | Homo sapiens (human) | Alpha-PAK,p21-activated kinase 1,PAK-1,p65-PAK |
| 2 | C, F (B, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 3 | D (A) | (3~{S})-3-[(~{Z})-[11-[2,2-bis(fluoranyl)ethyl]-8-chloranyl-3-fluoranyl-5~{H}-benzo[b][1,4]benzodiazepin-6-ylidene]amino]-~{N}-propan-2-yl-pyrrolidine-1-carboxamide | non-polymer | 479.9 | 1 | Chemie (A1JZR) | |||
| 4 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 5 | G, H (B, A) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
B, A: 249 - 545 (UniProt: Q13153)
| PDB | External Database | Details |
|---|---|---|
| Arg 299 | Lys 299 | engineered mutation |
| Asp 503 | Glu 503 | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66706.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 642.9 | |
| All* | Total formula weight | 67349.4 |
