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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

28OP

Structure of the human inner kinetochore CCAN and CENP-C bound to DNA

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(M)		Centromere protein Mpolymer18019761.91UniProt (Q9NSP4)Homo sapiens (human)
2B
(S)		Centromere protein Spolymer13815917.91UniProt (Q8N2Z9)Homo sapiens (human)
3C
(T)		Methylated-DNA--protein-cysteine methyltransferase,Centromere protein Tpolymer77784067.71UniProt (P16455)
UniProt (Q96BT3)		Homo sapiens (human)6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase,CENP-T,Interphase centromere complex protein 22
4D
(U)		Centromere protein Upolymer21124484.91UniProt (Q71F23)Homo sapiens (human)CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1
5E
(V)		DNA (59-MER)polymer21265387.71Homo sapiens
6F
(W)		Centromere protein Wpolymer8810087.21UniProt (Q5EE01)Homo sapiens (human)
7G
(X)		Centromere protein Xpolymer818972.41UniProt (A8MT69)Homo sapiens (human)
8H
(Y)		DNA (61-MER)polymer21265508.81Homo sapiens
9I
(H)		Centromere protein Hpolymer24728520.91UniProt (Q9H3R5)Homo sapiens (human)
10J
(I)		Centromere protein Ipolymer76287615.01UniProt (Q92674)Homo sapiens (human)CENP-I,FSH primary response protein 1,Follicle-stimulating hormone primary response protein,Interphase centromere complex protein 19,Leucine-rich primary response protein 1
11K
(K)		Centromere protein Kpolymer26931696.11UniProt (Q9BS16)Homo sapiens (human)
12L
(L)		Centromere protein Lpolymer34839364.01UniProt (Q8N0S6)Homo sapiens (human)CENP-L,Interphase centromere complex protein 33
13M
(N)		Centromere protein Npolymer34740541.61UniProt (Q96H22)Homo sapiens (human)CENP-N,Interphase centromere complex protein 32
14N
(O)		Centromere protein Opolymer30033830.61UniProt (Q9BU64)Homo sapiens (human)CENP-O,Interphase centromere complex protein 36
15O
(P)		Centromere protein Ppolymer28833210.91UniProt (Q6IPU0)Homo sapiens (human)
16P
(Q)		Centromere protein Qpolymer21524634.51UniProt (Q7L2Z9)Trichoplusia ni (cabbage looper)CENP-Q
17Q
(R)		Centromere protein Rpolymer17720228.31UniProt (Q13352)Homo sapiens (human)
18R
(C)		Centromere protein C,Methylated-DNA--protein-cysteine methyltransferasepolymer77586473.11UniProt (Q03188)
UniProt (P16455)		Homo sapiens (human)6-O-methylguanine-DNA methyltransferase,MGMT,O-6-methylguanine-DNA-alkyltransferase
Sequence modifications
T: -191 - -10 (UniProt: P16455)
PDBExternal DatabaseDetails
Met -215-initiating methionine
Ser -214-expression tag
Tyr -213-expression tag
Tyr -212-expression tag
His -211-expression tag
His -210-expression tag
His -209-expression tag
His -208-expression tag
His -207-expression tag
His -206-expression tag
Asp -205-expression tag
Tyr -204-expression tag
Asp -203-expression tag
Ile -202-expression tag
Pro -201-expression tag
Thr -200-expression tag
Thr -199-expression tag
Glu -198-expression tag
Asn -197-expression tag
Leu -196-expression tag
Tyr -195-expression tag
Phe -194-expression tag
Gln -193-expression tag
Gly -192-expression tag
Arg -162Glu 30conflict
Ile -160Lys 32conflict
Phe -159Leu 33conflict
Ala -130Cys 62conflict
Ser -77Gln 115conflict
His -76Gln 116conflict
Ala -67Lys 125conflict
Thr -65Ala 127conflict
Ala -64Arg 128conflict
Lys -61Gly 131conflict
Thr -60Gly 132conflict
Leu -58Met 134conflict
Ser -57Arg 135conflict
Gln -42Cys 150conflict
Gly -41Ser 151conflict
Asp -40Ser 152conflict
Leu -39Gly 153conflict
Asp -38Ala 154conflict
Gly -35Asn 157conflict
Glu -33Ser 159conflict
Ser -9-linker
Asp -8-linker
Leu -7-linker
Glu -6-linker
Val -5-linker
Leu -4-linker
Phe -3-linker
Gln -2-linker
Gly -1-linker
Pro 0-linker
T: 1 - 561 (UniProt: Q96BT3)
U: 243 - 418 (UniProt: Q71F23)
PDBExternal DatabaseDetails
Glu 419-expression tag
Asn 420-expression tag
Leu 421-expression tag
Tyr 422-expression tag
Phe 423-expression tag
Gln 424-expression tag
Ser 425-expression tag
Trp 426-expression tag
Ser 427-expression tag
His 428-expression tag
Pro 429-expression tag
Gln 430-expression tag
Phe 431-expression tag
Glu 432-expression tag
Lys 433-expression tag
Gly 434-expression tag
Gly 435-expression tag
Gly 436-expression tag
Ser 437-expression tag
Gly 438-expression tag
Gly 439-expression tag
Gly 440-expression tag
Ser 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Gly 444-expression tag
Ser 445-expression tag
Trp 446-expression tag
Ser 447-expression tag
His 448-expression tag
Pro 449-expression tag
Gln 450-expression tag
Phe 451-expression tag
Glu 452-expression tag
Lys 453-expression tag
I: 1 - 756 (UniProt: Q92674)
PDBExternal DatabaseDetails
Glu 757-expression tag
Asn 758-expression tag
Leu 759-expression tag
Tyr 760-expression tag
Phe 761-expression tag
Gln 762-expression tag
L: 1 - 344 (UniProt: Q8N0S6)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Leu -1-expression tag
Gly 0-expression tag
N: 1 - 339 (UniProt: Q96H22)
PDBExternal DatabaseDetails
Ser 340-expression tag
Asp 341-expression tag
Leu 342-expression tag
Glu 343-expression tag
Val 344-expression tag
Leu 345-expression tag
Phe 346-expression tag
Gln 347-expression tag
Q: 55 - 268 (UniProt: Q7L2Z9)
PDBExternal DatabaseDetails
Met 54-initiating methionine
C: 1 - 545 (UniProt: Q03188)
PDBExternal DatabaseDetails
Asp 546-linker
Leu 547-linker
Glu 548-linker
Val 549-linker
Leu 550-linker
Phe 551-linker
Gln 552-linker
Gly 553-linker
Pro 554-linker
Leu 555-linker
Gly 556-linker
C: 557 - 738 (UniProt: P16455)
PDBExternal DatabaseDetails
Arg 586Glu 30conflict
Ile 588Lys 32conflict
Phe 589Leu 33conflict
Ala 618Cys 62conflict
Ser 671Gln 115conflict
His 672Gln 116conflict
Ala 681Lys 125conflict
Thr 683Ala 127conflict
Ala 684Arg 128conflict
Lys 687Gly 131conflict
Thr 688Gly 132conflict
Leu 690Met 134conflict
Ser 691Arg 135conflict
Gln 706Cys 150conflict
Gly 707Ser 151conflict
Asp 708Ser 152conflict
Leu 709Gly 153conflict
Asp 710Ala 154conflict
Gly 713Asn 157conflict
Glu 715Ser 159conflict
Glu 739-expression tag
Asn 740-expression tag
Leu 741-expression tag
Tyr 742-expression tag
Phe 743-expression tag
Gln 744-expression tag
Ser 745-expression tag
Ser 746-expression tag
Ala 747-expression tag
Trp 748-expression tag
Ser 749-expression tag
His 750-expression tag
Pro 751-expression tag
Gln 752-expression tag
Phe 753-expression tag
Glu 754-expression tag
Lys 755-expression tag
Gly 756-expression tag
Gly 757-expression tag
Gly 758-expression tag
Ser 759-expression tag
Gly 760-expression tag
Gly 761-expression tag
Gly 762-expression tag
Ser 763-expression tag
Gly 764-expression tag
Gly 765-expression tag
Ser 766-expression tag
Ala 767-expression tag
Trp 768-expression tag
Ser 769-expression tag
His 770-expression tag
Pro 771-expression tag
Gln 772-expression tag
Phe 773-expression tag
Glu 774-expression tag
Lys 775-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains18
Total formula weight720303.7
All*Total formula weight720303.7
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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