Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

28OP

Structure of the human inner kinetochore CCAN and CENP-C bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000776	cellular_component	kinetochore
H	0000939	cellular_component	inner kinetochore
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0007052	biological_process	mitotic spindle organization
H	0007059	biological_process	chromosome segregation
H	0043515	molecular_function	kinetochore binding
H	0051383	biological_process	kinetochore organization
I	0000070	biological_process	mitotic sister chromatid segregation
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000939	cellular_component	inner kinetochore
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0007059	biological_process	chromosome segregation
I	0007548	biological_process	sex differentiation
I	0016604	cellular_component	nuclear body
I	0034080	biological_process	CENP-A containing chromatin assembly
K	0000775	cellular_component	chromosome, centromeric region
K	0000939	cellular_component	inner kinetochore
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005829	cellular_component	cytosol
K	0007059	biological_process	chromosome segregation
L	0000775	cellular_component	chromosome, centromeric region
L	0000939	cellular_component	inner kinetochore
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005829	cellular_component	cytosol
L	0007059	biological_process	chromosome segregation
M	0000939	cellular_component	inner kinetochore
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007059	biological_process	chromosome segregation
N	0000939	cellular_component	inner kinetochore
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0007059	biological_process	chromosome segregation
O	0000775	cellular_component	chromosome, centromeric region
O	0000939	cellular_component	inner kinetochore
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0007059	biological_process	chromosome segregation
O	0016604	cellular_component	nuclear body
O	0031511	cellular_component	Mis6-Sim4 complex
P	0000775	cellular_component	chromosome, centromeric region
P	0000939	cellular_component	inner kinetochore
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005829	cellular_component	cytosol
P	0007059	biological_process	chromosome segregation
R	0000775	cellular_component	chromosome, centromeric region
R	0000939	cellular_component	inner kinetochore
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0007059	biological_process	chromosome segregation
R	0007155	biological_process	cell adhesion
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
S	0000712	biological_process	resolution of meiotic recombination intermediates
S	0000775	cellular_component	chromosome, centromeric region
S	0000785	cellular_component	chromatin
S	0000939	cellular_component	inner kinetochore
S	0003677	molecular_function	DNA binding
S	0003682	molecular_function	chromatin binding
S	0003690	molecular_function	double-stranded DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005829	cellular_component	cytosol
S	0006281	biological_process	DNA repair
S	0006974	biological_process	DNA damage response
S	0007059	biological_process	chromosome segregation
S	0031297	biological_process	replication fork processing
S	0031398	biological_process	positive regulation of protein ubiquitination
S	0036297	biological_process	interstrand cross-link repair
S	0043240	cellular_component	Fanconi anaemia nuclear complex
S	0071821	cellular_component	FANCM-MHF complex
T	0000278	biological_process	mitotic cell cycle
T	0000775	cellular_component	chromosome, centromeric region
T	0000776	cellular_component	kinetochore
T	0000939	cellular_component	inner kinetochore
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005829	cellular_component	cytosol
T	0007059	biological_process	chromosome segregation
T	0016604	cellular_component	nuclear body
T	0051276	biological_process	chromosome organization
T	0051382	biological_process	kinetochore assembly
W	0000278	biological_process	mitotic cell cycle
W	0000775	cellular_component	chromosome, centromeric region
W	0000776	cellular_component	kinetochore
W	0000939	cellular_component	inner kinetochore
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0007059	biological_process	chromosome segregation
W	0016363	cellular_component	nuclear matrix
W	0034080	biological_process	CENP-A containing chromatin assembly
W	0051276	biological_process	chromosome organization
W	0051382	biological_process	kinetochore assembly
X	0000712	biological_process	resolution of meiotic recombination intermediates
X	0000775	cellular_component	chromosome, centromeric region
X	0000785	cellular_component	chromatin
X	0000939	cellular_component	inner kinetochore
X	0003677	molecular_function	DNA binding
X	0003690	molecular_function	double-stranded DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005829	cellular_component	cytosol
X	0007059	biological_process	chromosome segregation
X	0031297	biological_process	replication fork processing
X	0031398	biological_process	positive regulation of protein ubiquitination
X	0036297	biological_process	interstrand cross-link repair
X	0043240	cellular_component	Fanconi anaemia nuclear complex
X	0071821	cellular_component	FANCM-MHF complex

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
C	ILE699-VAL705
T	ILE-49-VAL-43

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	99
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	31
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Breakpoint for translocation to form KMT2A/MLL1-CENPK oncogene"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Motif: {"description":"LXXIL motif"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)