26JZ

Cryo-EM structure of Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with 5'/3' vRNA dual-promotor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase L	polymer	3974	451547.6	1	UniProt (Q6TQR6)	Orthonairovirus haemorrhagiae	Protein L,Large structural protein,Replicase,Transcriptase
2	B (B)	5' vRNA promoter	polymer	15	4737.9	1		Orthonairovirus haemorrhagiae
3	C (C)	3' vRNA promoter	polymer	26	8458.0	1		Orthonairovirus haemorrhagiae
4	D, E (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)
5	F (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN) PubChem (27854)
6	G (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)

Sequence modifications

A: 1 - 3945 (UniProt: Q6TQR6)

PDB	External Database	Details
Trp 3946	-	expression tag
Ser 3947	-	expression tag
His 3948	-	expression tag
Pro 3949	-	expression tag
Gln 3950	-	expression tag
Phe 3951	-	expression tag
Glu 3952	-	expression tag
Lys 3953	-	expression tag
Gly 3954	-	expression tag
Ser 3955	-	expression tag
Ser 3956	-	expression tag
Gly 3957	-	expression tag
Gly 3958	-	expression tag
Ser 3959	-	expression tag
Ser 3960	-	expression tag
Gly 3961	-	expression tag
Ser 3962	-	expression tag
Ser 3963	-	expression tag
Gly 3964	-	expression tag
Gly 3965	-	expression tag
Ala 3966	-	expression tag
Trp 3967	-	expression tag
Ser 3968	-	expression tag
His 3969	-	expression tag
Pro 3970	-	expression tag
Gln 3971	-	expression tag
Phe 3972	-	expression tag
Glu 3973	-	expression tag
Lys 3974	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	464743.5
Non-Polymers*	Number of molecules	4
	Total formula weight	210.1
All*	Total formula weight	464953.6

*Water molecules are not included.