25VX
Crystal Structure of MYST histone acetyltransferase KAT6A in complex with inhibitor Compound 9
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase KAT8 | polymer | 271 | 31945.8 | 1 | UniProt (Q9H7Z6) Pfam (PF17772) Pfam (PF01853) | Homo sapiens (human) | Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,MYST-1,Males-absent on the first protein homolog,hMOF,Protein acetyltransferase KAT8,Protein propionyltransferase KAT8 |
| 2 | B (A) | 2,6-dimethoxy-~{N}-(5-phenyl-3,4-dihydro-2~{H}-pyrano[2,3-e][1,2]benzoxazol-9-yl)benzenesulfonamide | non-polymer | 466.5 | 1 | Chemie (A1MGC) | |||
| 3 | C (A) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A: 506 - 776 (UniProt: Q9H7Z6)
| PDB | External Database | Details |
|---|---|---|
| His 579 | Tyr 249 | engineered mutation |
| Ser 645 | Ala 315 | engineered mutation |
| Met 648 | Leu 318 | engineered mutation |
| Ile 649 | Thr 319 | engineered mutation |
| Arg 660 | Lys 330 | engineered mutation |
| Asn 702 | Ile 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31945.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.5 | |
| All* | Total formula weight | 32412.3 |
