24RC
Cryo-EM structure of human sodium pump W931R mutant in K+-occluded E2-Pi state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium/potassium-transporting ATPase subunit alpha-1 | polymer | 984 | 108652.8 | 1 | UniProt (P05023) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF00689) | Homo sapiens (human) | Na(+)/K(+) ATPase alpha-1 subunit,Sodium pump subunit alpha-1 |
| 2 | B (B) | Sodium/potassium-transporting ATPase subunit beta-3 | polymer | 268 | 30240.0 | 1 | UniProt (P54709) Pfam (PF00287) | Homo sapiens (human) | Sodium/potassium-dependent ATPase subunit beta-3,ATPB-3 |
| 3 | C (A) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) PubChem (5311325) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E, F, G (A) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) PubChem (813) | |||
| 6 | H, I, K, L, M... (A, B) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 6 | Chemie (PCW) | |||
| 7 | J, O, P (A, B) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (5997) | |||
| 8 | Q, R (A, B) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 40 - 1023 (UniProt: P05023)
| PDB | External Database | Details |
|---|---|---|
| Arg 931 | Trp 931 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 138892.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 6127.3 | |
| All* | Total formula weight | 145020.1 |
