24HT
Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP2527
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 179 | 20150.6 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | B (I) | AP2527 | polymer | 11 | 1355.0 | 1 | synthetic construct | ||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 4 | D, E, F, G, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | H (A) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 6 | K (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 7 | L, M (A, I) | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21505.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 900.0 | |
| All* | Total formula weight | 22405.6 |
