24HS
Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP4959
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Isoform 2B of GTPase KRas | polymer | 179 | 20150.6 | 8 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | I, J, K, L, M... (I, J, K, L, M...) | AP4959 | polymer | 12 | 1417.7 | 8 | synthetic construct | ||
| 3 | AA, EA, GA, JA, MA... (C, D, E, F, G...) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 8 | Chemie (GDP) | |||
| 4 | BA, CA, HA, KA, R... (C, E, F, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | DA, FA, IA, LA, NA... (C, D, E, F, G...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) PubChem (888) | |||
| 6 | AB, BB, QA, RA, SA... (K, L, A, B, C...) | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 172546.4 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 4360.7 | |
| All* | Total formula weight | 176907.1 |
