24HS

Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP4959

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000165	biological_process	MAPK cascade
A	0001889	biological_process	liver development
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0007249	biological_process	canonical NF-kappaB signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0007565	biological_process	female pregnancy
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009629	biological_process	response to gravity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010628	biological_process	positive regulation of gene expression
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0019002	molecular_function	GMP binding
A	0019003	molecular_function	GDP binding
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030275	molecular_function	LRR domain binding
A	0032008	biological_process	positive regulation of TOR signaling
A	0035900	biological_process	response to isolation stress
A	0042127	biological_process	regulation of cell population proliferation
A	0043069	biological_process	negative regulation of programmed cell death
A	0043410	biological_process	positive regulation of MAPK cascade
A	0044877	molecular_function	protein-containing complex binding
A	0046579	biological_process	positive regulation of Ras protein signal transduction
A	0051384	biological_process	response to glucocorticoid
A	0051385	biological_process	response to mineralocorticoid
A	0051450	biological_process	myoblast proliferation
A	0060038	biological_process	cardiac muscle cell proliferation
A	1902554	cellular_component	serine/threonine protein kinase complex
A	1905360	cellular_component	GTPase complex
A	2000774	biological_process	positive regulation of cellular senescence
B	0000139	cellular_component	Golgi membrane
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0000165	biological_process	MAPK cascade
B	0001889	biological_process	liver development
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005741	cellular_component	mitochondrial outer membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0007249	biological_process	canonical NF-kappaB signal transduction
B	0007265	biological_process	Ras protein signal transduction
B	0007565	biological_process	female pregnancy
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009629	biological_process	response to gravity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010628	biological_process	positive regulation of gene expression
B	0012505	cellular_component	endomembrane system
B	0016020	cellular_component	membrane
B	0019002	molecular_function	GMP binding
B	0019003	molecular_function	GDP binding
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030275	molecular_function	LRR domain binding
B	0032008	biological_process	positive regulation of TOR signaling
B	0035900	biological_process	response to isolation stress
B	0042127	biological_process	regulation of cell population proliferation
B	0043069	biological_process	negative regulation of programmed cell death
B	0043410	biological_process	positive regulation of MAPK cascade
B	0044877	molecular_function	protein-containing complex binding
B	0046579	biological_process	positive regulation of Ras protein signal transduction
B	0051384	biological_process	response to glucocorticoid
B	0051385	biological_process	response to mineralocorticoid
B	0051450	biological_process	myoblast proliferation
B	0060038	biological_process	cardiac muscle cell proliferation
B	1902554	cellular_component	serine/threonine protein kinase complex
B	1905360	cellular_component	GTPase complex
B	2000774	biological_process	positive regulation of cellular senescence
C	0000139	cellular_component	Golgi membrane
C	0000164	cellular_component	protein phosphatase type 1 complex
C	0000165	biological_process	MAPK cascade
C	0001889	biological_process	liver development
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005741	cellular_component	mitochondrial outer membrane
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0007249	biological_process	canonical NF-kappaB signal transduction
C	0007265	biological_process	Ras protein signal transduction
C	0007565	biological_process	female pregnancy
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009629	biological_process	response to gravity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0010628	biological_process	positive regulation of gene expression
C	0012505	cellular_component	endomembrane system
C	0016020	cellular_component	membrane
C	0019002	molecular_function	GMP binding
C	0019003	molecular_function	GDP binding
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030275	molecular_function	LRR domain binding
C	0032008	biological_process	positive regulation of TOR signaling
C	0035900	biological_process	response to isolation stress
C	0042127	biological_process	regulation of cell population proliferation
C	0043069	biological_process	negative regulation of programmed cell death
C	0043410	biological_process	positive regulation of MAPK cascade
C	0044877	molecular_function	protein-containing complex binding
C	0046579	biological_process	positive regulation of Ras protein signal transduction
C	0051384	biological_process	response to glucocorticoid
C	0051385	biological_process	response to mineralocorticoid
C	0051450	biological_process	myoblast proliferation
C	0060038	biological_process	cardiac muscle cell proliferation
C	1902554	cellular_component	serine/threonine protein kinase complex
C	1905360	cellular_component	GTPase complex
C	2000774	biological_process	positive regulation of cellular senescence
D	0000139	cellular_component	Golgi membrane
D	0000164	cellular_component	protein phosphatase type 1 complex
D	0000165	biological_process	MAPK cascade
D	0001889	biological_process	liver development
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005741	cellular_component	mitochondrial outer membrane
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0007249	biological_process	canonical NF-kappaB signal transduction
D	0007265	biological_process	Ras protein signal transduction
D	0007565	biological_process	female pregnancy
D	0008284	biological_process	positive regulation of cell population proliferation
D	0009629	biological_process	response to gravity
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0010628	biological_process	positive regulation of gene expression
D	0012505	cellular_component	endomembrane system
D	0016020	cellular_component	membrane
D	0019002	molecular_function	GMP binding
D	0019003	molecular_function	GDP binding
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030275	molecular_function	LRR domain binding
D	0032008	biological_process	positive regulation of TOR signaling
D	0035900	biological_process	response to isolation stress
D	0042127	biological_process	regulation of cell population proliferation
D	0043069	biological_process	negative regulation of programmed cell death
D	0043410	biological_process	positive regulation of MAPK cascade
D	0044877	molecular_function	protein-containing complex binding
D	0046579	biological_process	positive regulation of Ras protein signal transduction
D	0051384	biological_process	response to glucocorticoid
D	0051385	biological_process	response to mineralocorticoid
D	0051450	biological_process	myoblast proliferation
D	0060038	biological_process	cardiac muscle cell proliferation
D	1902554	cellular_component	serine/threonine protein kinase complex
D	1905360	cellular_component	GTPase complex
D	2000774	biological_process	positive regulation of cellular senescence
E	0000139	cellular_component	Golgi membrane
E	0000164	cellular_component	protein phosphatase type 1 complex
E	0000165	biological_process	MAPK cascade
E	0001889	biological_process	liver development
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005741	cellular_component	mitochondrial outer membrane
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0007249	biological_process	canonical NF-kappaB signal transduction
E	0007265	biological_process	Ras protein signal transduction
E	0007565	biological_process	female pregnancy
E	0008284	biological_process	positive regulation of cell population proliferation
E	0009629	biological_process	response to gravity
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0010628	biological_process	positive regulation of gene expression
E	0012505	cellular_component	endomembrane system
E	0016020	cellular_component	membrane
E	0019002	molecular_function	GMP binding
E	0019003	molecular_function	GDP binding
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0030275	molecular_function	LRR domain binding
E	0032008	biological_process	positive regulation of TOR signaling
E	0035900	biological_process	response to isolation stress
E	0042127	biological_process	regulation of cell population proliferation
E	0043069	biological_process	negative regulation of programmed cell death
E	0043410	biological_process	positive regulation of MAPK cascade
E	0044877	molecular_function	protein-containing complex binding
E	0046579	biological_process	positive regulation of Ras protein signal transduction
E	0051384	biological_process	response to glucocorticoid
E	0051385	biological_process	response to mineralocorticoid
E	0051450	biological_process	myoblast proliferation
E	0060038	biological_process	cardiac muscle cell proliferation
E	1902554	cellular_component	serine/threonine protein kinase complex
E	1905360	cellular_component	GTPase complex
E	2000774	biological_process	positive regulation of cellular senescence
F	0000139	cellular_component	Golgi membrane
F	0000164	cellular_component	protein phosphatase type 1 complex
F	0000165	biological_process	MAPK cascade
F	0001889	biological_process	liver development
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005741	cellular_component	mitochondrial outer membrane
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0007249	biological_process	canonical NF-kappaB signal transduction
F	0007265	biological_process	Ras protein signal transduction
F	0007565	biological_process	female pregnancy
F	0008284	biological_process	positive regulation of cell population proliferation
F	0009629	biological_process	response to gravity
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0010628	biological_process	positive regulation of gene expression
F	0012505	cellular_component	endomembrane system
F	0016020	cellular_component	membrane
F	0019002	molecular_function	GMP binding
F	0019003	molecular_function	GDP binding
F	0019221	biological_process	cytokine-mediated signaling pathway
F	0030275	molecular_function	LRR domain binding
F	0032008	biological_process	positive regulation of TOR signaling
F	0035900	biological_process	response to isolation stress
F	0042127	biological_process	regulation of cell population proliferation
F	0043069	biological_process	negative regulation of programmed cell death
F	0043410	biological_process	positive regulation of MAPK cascade
F	0044877	molecular_function	protein-containing complex binding
F	0046579	biological_process	positive regulation of Ras protein signal transduction
F	0051384	biological_process	response to glucocorticoid
F	0051385	biological_process	response to mineralocorticoid
F	0051450	biological_process	myoblast proliferation
F	0060038	biological_process	cardiac muscle cell proliferation
F	1902554	cellular_component	serine/threonine protein kinase complex
F	1905360	cellular_component	GTPase complex
F	2000774	biological_process	positive regulation of cellular senescence
G	0000139	cellular_component	Golgi membrane
G	0000164	cellular_component	protein phosphatase type 1 complex
G	0000165	biological_process	MAPK cascade
G	0001889	biological_process	liver development
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005741	cellular_component	mitochondrial outer membrane
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0007249	biological_process	canonical NF-kappaB signal transduction
G	0007265	biological_process	Ras protein signal transduction
G	0007565	biological_process	female pregnancy
G	0008284	biological_process	positive regulation of cell population proliferation
G	0009629	biological_process	response to gravity
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0010628	biological_process	positive regulation of gene expression
G	0012505	cellular_component	endomembrane system
G	0016020	cellular_component	membrane
G	0019002	molecular_function	GMP binding
G	0019003	molecular_function	GDP binding
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0030275	molecular_function	LRR domain binding
G	0032008	biological_process	positive regulation of TOR signaling
G	0035900	biological_process	response to isolation stress
G	0042127	biological_process	regulation of cell population proliferation
G	0043069	biological_process	negative regulation of programmed cell death
G	0043410	biological_process	positive regulation of MAPK cascade
G	0044877	molecular_function	protein-containing complex binding
G	0046579	biological_process	positive regulation of Ras protein signal transduction
G	0051384	biological_process	response to glucocorticoid
G	0051385	biological_process	response to mineralocorticoid
G	0051450	biological_process	myoblast proliferation
G	0060038	biological_process	cardiac muscle cell proliferation
G	1902554	cellular_component	serine/threonine protein kinase complex
G	1905360	cellular_component	GTPase complex
G	2000774	biological_process	positive regulation of cellular senescence
H	0000139	cellular_component	Golgi membrane
H	0000164	cellular_component	protein phosphatase type 1 complex
H	0000165	biological_process	MAPK cascade
H	0001889	biological_process	liver development
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005741	cellular_component	mitochondrial outer membrane
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0007249	biological_process	canonical NF-kappaB signal transduction
H	0007265	biological_process	Ras protein signal transduction
H	0007565	biological_process	female pregnancy
H	0008284	biological_process	positive regulation of cell population proliferation
H	0009629	biological_process	response to gravity
H	0009898	cellular_component	cytoplasmic side of plasma membrane
H	0010628	biological_process	positive regulation of gene expression
H	0012505	cellular_component	endomembrane system
H	0016020	cellular_component	membrane
H	0019002	molecular_function	GMP binding
H	0019003	molecular_function	GDP binding
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0030275	molecular_function	LRR domain binding
H	0032008	biological_process	positive regulation of TOR signaling
H	0035900	biological_process	response to isolation stress
H	0042127	biological_process	regulation of cell population proliferation
H	0043069	biological_process	negative regulation of programmed cell death
H	0043410	biological_process	positive regulation of MAPK cascade
H	0044877	molecular_function	protein-containing complex binding
H	0046579	biological_process	positive regulation of Ras protein signal transduction
H	0051384	biological_process	response to glucocorticoid
H	0051385	biological_process	response to mineralocorticoid
H	0051450	biological_process	myoblast proliferation
H	0060038	biological_process	cardiac muscle cell proliferation
H	1902554	cellular_component	serine/threonine protein kinase complex
H	1905360	cellular_component	GTPase complex
H	2000774	biological_process	positive regulation of cellular senescence

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"40934300","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"9MF0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"40934300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9MF0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---