22RD
High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 333 | 37480.6 | 1 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | |
| 2 | B (A) | 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE | non-polymer | 532.5 | 1 | Chemie (937) PubChem (49792852) |
Sequence modifications
A: 13 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Val 210 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37480.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 532.5 | |
| All* | Total formula weight | 38013.1 |
