22JX
Cryo-EM structure of the mGlu5-beta-arrestin 1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 5 | polymer | 892 | 100125.0 | 2 | UniProt (P41594) | Homo sapiens (human) | mGluR5 |
| 2 | C, D, F, H (C, D, F, H) | beta-arrestin 1 | polymer | 522 | 58500.0 | 4 | Homo sapiens | ||
| 3 | E, G (E, G) | scFv30 | polymer | 111 | 11976.3 | 2 | Mus musculus | ||
| 4 | I, K (A, B) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) PubChem (33032) | |||
| 5 | J, L (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A, B: 22 - 865 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Gly -26 | - | expression tag |
| Ser -25 | - | expression tag |
| Trp -24 | - | expression tag |
| Ser -23 | - | expression tag |
| His -22 | - | expression tag |
| Pro -21 | - | expression tag |
| Gln -20 | - | expression tag |
| Phe -19 | - | expression tag |
| Glu -18 | - | expression tag |
| Lys -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Ala -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ala -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Trp -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Lys 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Asp 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Lys 6 | - | expression tag |
| Asp 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Asp 10 | - | expression tag |
| Lys 11 | - | expression tag |
| Glu 12 | - | expression tag |
| Phe 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Glu 15 | - | expression tag |
| Val 16 | - | expression tag |
| Leu 17 | - | expression tag |
| Phe 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Pro 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 458202.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 736.7 | |
| All* | Total formula weight | 458939.1 |
