22GM
C5a bound C5aR1 in complex with beta-arrestin1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | C5a anaphylatoxin | polymer | 74 | 8342.7 | 1 | UniProt (P01031) | Homo sapiens (human) | |
| 2 | B (R) | C5a anaphylatoxin chemotactic receptor 1,Vasopressin V2 receptor | polymer | 371 | 41403.6 | 1 | UniProt (P21730) UniProt (P30518) | Homo sapiens (human) | C5a anaphylatoxin chemotactic receptor,C5a-R,C5aR,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 3 | C (H) | Fab30 heavy chain | polymer | 193 | 20906.5 | 1 | Mus musculus | ||
| 4 | D (L) | Fab30 light chain | polymer | 164 | 17692.6 | 1 | Homo sapiens | ||
| 5 | E (A) | Beta-arrestin-1 | polymer | 347 | 38980.8 | 1 | UniProt (P17870) | Bos taurus (Bovine) | Arrestin beta-1,Arrestin-2 |
Sequence modifications
C: 1 - 74 (UniProt: P01031)
R: 1 - 330 (UniProt: P21730)
R: 343 - 371 (UniProt: P30518)
A: 6 - 352 (UniProt: P17870)
| PDB | External Database | Details |
|---|---|---|
| Arg 27 | Cys 704 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 331 | - | linker |
| Gly 332 | - | linker |
| Gly 333 | - | linker |
| Ser 334 | - | linker |
| Gly 335 | - | linker |
| Gly 336 | - | linker |
| Gly 337 | - | linker |
| Ser 338 | - | linker |
| Gly 339 | - | linker |
| Gly 340 | - | linker |
| Ala 341 | - | linker |
| Ser 342 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Glu 347 | Thr 347 | conflict |
| Glu 350 | Ser 350 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Arg 169 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 127326.3 | |
| All* | Total formula weight | 127326.3 |
