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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

22GM

C5a bound C5aR1 in complex with beta-arrestin1

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLLATISADRFLlV
ChainResidueDetails
RALA122-VAL138
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR180-HIS186
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79
site_idPS01177
Number of Residues35
DetailsANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGarvnnde.TCEqraarisl.GprCikafte.CC
ChainResidueDetails
CCYS21-CYS55
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues34
DetailsDomain: {"description":"Anaphylatoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00022","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues29
DetailsRegion: {"description":"Involved in C5AR1 binding","evidences":[{"source":"PubMed","id":"9553099","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues39
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues57
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7642584","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues27
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues41
DetailsRegion: {"description":"Interaction with CHRM2"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-07-22

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