Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

22GM

C5a bound C5aR1 in complex with beta-arrestin1

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0001774	biological_process	microglial cell activation
R	0002430	biological_process	complement receptor mediated signaling pathway
R	0004878	molecular_function	complement component C5a receptor activity
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005515	molecular_function	protein binding
R	0005886	cellular_component	plasma membrane
R	0006935	biological_process	chemotaxis
R	0006955	biological_process	immune response
R	0006968	biological_process	cellular defense response
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
R	0007606	biological_process	sensory perception of chemical stimulus
R	0010575	biological_process	positive regulation of vascular endothelial growth factor production
R	0010759	biological_process	positive regulation of macrophage chemotaxis
R	0016323	cellular_component	basolateral plasma membrane
R	0030667	cellular_component	secretory granule membrane
R	0031410	cellular_component	cytoplasmic vesicle
R	0038178	biological_process	complement component C5a signaling pathway
R	0042789	biological_process	mRNA transcription by RNA polymerase II
R	0045177	cellular_component	apical part of cell
R	0045766	biological_process	positive regulation of angiogenesis
R	0048143	biological_process	astrocyte activation
R	0050679	biological_process	positive regulation of epithelial cell proliferation
R	0050890	biological_process	cognition
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	0090023	biological_process	positive regulation of neutrophil chemotaxis
R	0097242	biological_process	amyloid-beta clearance
R	0099172	biological_process	presynapse organization

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLLATISADRFLlV

Chain	Residue	Details
R	ALA122-VAL138

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR180-HIS186

site_id	PS00295
Number of Residues	19
Details	ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL

Chain	Residue	Details
A	PHE61-LEU79

site_id	PS01177
Number of Residues	35
Details	ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGarvnnde.TCEqraarisl.GprCikafte.CC

Chain	Residue	Details
C	CYS21-CYS55

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Domain: {"description":"Anaphylatoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00022","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	29
Details	Region: {"description":"Involved in C5AR1 binding","evidences":[{"source":"PubMed","id":"9553099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	39
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	57
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29300009","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37169960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37852260","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IA2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7642584","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	27
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"33742150","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DW9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	41
Details	Region: {"description":"Interaction with CHRM2"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)