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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

22ES

Gi bound kappa-opioid receptor in complex with difelikefalin

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35439151.91UniProt (P54311)
Pfam (PF25391)		Rattus norvegicus (Norway rat)Transducin beta chain 1
2B
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P63212)
Pfam (PF00631)		Bos taurus (domestic cattle)G gamma-I
3C
(R)		Kappa-type opioid receptorpolymer39744780.11UniProt (P41145)
Pfam (PF00001)		Homo sapiens (human)K-OR-1,KOR-1
4D
(D)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
5E
(E)		scFv16polymer26628606.71synthetic construct
6F
(A)		DPN-DPN-DLE-DLY-A1L9Xpolymer5679.91synthetic construct
7G, H, I
(R)		CHOLESTEROLnon-polymer386.73Chemie (CLR)
PubChem (16219173)
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PubChem (304)
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PubChem (42579431)
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PubChem (191463)
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PubChem (66634651)
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PubChem (68315613)
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PubChem (70795838)
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PubChem (124146240)
PubChem (7059399)
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PubChem (132837164)
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PubChem (7059400)
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PubChem (11869367)
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PubChem (12303156)
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PubChem (15939944)
PubChem (124909223)
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PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
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PubChem (145215073)
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PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -13-initiating methionine
His -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
Met -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
R: 3 - 380 (UniProt: P41145)
PDBExternal DatabaseDetails
Asp -8-expression tag
Tyr -7-expression tag
Lys -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Val -1-expression tag
Asp 0-expression tag
Ala 1-expression tag
Ser 2-expression tag
His 381-expression tag
His 382-expression tag
His 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
His 387-expression tag
His 388-expression tag
D: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47engineered mutation
Ala 203Gly 203engineered mutation
Ala 245Glu 245engineered mutation
Ser 326Ala 326engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight161493.7
Non-Polymers*Number of molecules3
Total formula weight1160.0
All*Total formula weight162653.7
*Water molecules are not included.

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PDB entries from 2026-05-13

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