21TL
Enterovirus 71 Polymerase Elongation Complex with a remdesivir nucleotide at product strand positions +1 (C1S5 form)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Enterovirus 71 polymerase | polymer | 468 | 53538.8 | 1 | UniProt (Q5DW46) | Enterovirus A71 | |
| 2 | B (C) | RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*CP*UP*CP*U*(F86))-3') | polymer | 15 | 4753.9 | 1 | synthetic construct | ||
| 3 | C (B) | RNA (33-MER) | polymer | 33 | 10696.4 | 1 | synthetic construct | ||
| 4 | D, E (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 6 | G (C) | [(2~{R},3~{S},4~{R},5~{R})-5-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | non-polymer | 371.2 | 1 | Chemie (F86) PubChem (121310009) | |||
| 7 | H (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 462 (UniProt: Q5DW46)
| PDB | External Database | Details |
|---|---|---|
| His 463 | - | expression tag |
| His 464 | - | expression tag |
| His 465 | - | expression tag |
| His 466 | - | expression tag |
| His 467 | - | expression tag |
| His 468 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68989.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 628.8 | |
| All* | Total formula weight | 69617.9 |
