21FS

Cryo-EM structure of human organic solute transporter OSTalpha/beta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Organic solute transporter subunit alpha	polymer	360	40341.6	2	UniProt (Q86UW1)	Homo sapiens (human)	OST-alpha,Solute carrier family 51 subunit alpha
2	B, D (B, D)	Organic solute transporter subunit beta	polymer	128	14361.3	2	UniProt (Q86UW2)	Homo sapiens (human)	OST-beta,Solute carrier family 51 subunit beta
3	E, O (A, C)	1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE	non-polymer		535.7	2	Chemie (PX2)
4	F, G, P, Q (A, C)	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR) PubChem (5997)
5	H, I, J, K, L... (A, C)	PALMITIC ACID	non-polymer		256.4	14	Chemie (PLM) PubChem (985)

Sequence modifications

A, C: 1 - 340 (UniProt: Q86UW1)

PDB	External Database	Details
Leu 341	-	expression tag
Glu 342	-	expression tag
Asp 343	-	expression tag
Tyr 344	-	expression tag
Lys 345	-	expression tag
Asp 346	-	expression tag
Asp 347	-	expression tag
Asp 348	-	expression tag
Asp 349	-	expression tag
Lys 350	-	expression tag
Val 351	-	expression tag
Glu 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag
His 357	-	expression tag
His 358	-	expression tag
His 359	-	expression tag
His 360	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	109405.7
Non-Polymers*	Number of molecules	20
	Total formula weight	6207.9
All*	Total formula weight	115613.6

*Water molecules are not included.