21AG

LY334370-bound serotonin 1F (5-HT1F) receptor-miniGoA protein complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	358	39418.1	1	UniProt (P62873)	Homo sapiens (human)
2	B (C)	Guanine nucleotide-binding protein G(o) subunit alpha	polymer	228	25435.1	1	UniProt (P09471)	Homo sapiens (human)
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768)	Homo sapiens (human)	G gamma-I
4	D (R)	5-hydroxytryptamine receptor 1F	polymer	366	41762.0	1	UniProt (P30939)	Homo sapiens (human)	5-HT-1F,5-HT1F,Serotonin receptor 1F
5	E (S)	scFv16	polymer	267	28668.9	1		Mus musculus
6	F (R)	4-fluoranyl-~{N}-[3-(1-methylpiperidin-4-yl)-1~{H}-indol-5-yl]benzamide	non-polymer		351.4	1	Chemie (A1E2G)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Leu -10	-	expression tag
Glu -9	-	expression tag
Val -8	-	expression tag
Leu -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

C: 4 - 51 (UniProt: P09471)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag
Met 3	-	expression tag
Asp 9	Glu 9	conflict
Lys 10	Arg 10	conflict
Val 13	Leu 13	conflict
Met 18	Ala 18	conflict
Asp 42	Gly 42	conflict
Asn 43	Glu 43	conflict

C: 182 - 354 (UniProt: P09471)

PDB	External Database	Details
Gln 168	-	linker
Met 169	-	linker
Lys 170	-	linker
Ile 171	-	linker
Ile 172	-	linker
His 173	-	linker
Gly 174	-	linker
Gly 175	-	linker
Ser 176	-	linker
Gly 177	-	linker
Gly 178	-	linker
Ser 179	-	linker
Gly 180	-	linker
Gly 181	-	linker
Asp 227	Ala 227	conflict
Asp 230	Gly 230	conflict
-	Asp 232	deletion
-	Gln 233	deletion
-	Val 234	deletion
-	Leu 235	deletion
-	His 236	deletion
-	Glu 237	deletion
-	Asp 238	deletion
-	Glu 239	deletion
-	Thr 240	deletion
-	Thr 241	deletion
Ala 332	Ile 332	conflict
Ile 335	Val 335	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	143145.2
Non-Polymers*	Number of molecules	1
	Total formula weight	351.4
All*	Total formula weight	143496.6

*Water molecules are not included.