1ZY8
The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dihydrolipoyl dehydrogenase, mitochondrial | polymer | 474 | 50236.5 | 10 | UniProt (P09622) Pfam (PF07992) Pfam (PF02852) | Homo sapiens (human) | Dihydrolipoamide dehydrogenase, Glycine cleavage system L protein |
| 2 | K, L, M, N, O (K, L, M, N, O) | Pyruvate dehydrogenase protein X component, mitochondrial | polymer | 229 | 24449.8 | 5 | UniProt (O00330) Pfam (PF00364) Pfam (PF02817) | Homo sapiens (human) | Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, Lipoyl-containing pyruvate dehydrogenase complex component X, E3-binding protein, E3BP, proX |
| 3 | P, Q, R, S, T... (A, B, C, D, E...) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 10 | Chemie (FAD) | |||
| 4 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 492 | Chemie (HOH) |
Sequence modifications
K, L, M, N, O: 1 - 221 (UniProt: O00330)
| PDB | External Database | Details |
|---|---|---|
| Leu 222 | - | cloning artifact |
| Glu 223 | - | cloning artifact |
| His 224 | - | expression tag |
| His 225 | - | expression tag |
| His 226 | - | expression tag |
| His 227 | - | expression tag |
| His 228 | - | expression tag |
| His 229 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 624614.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 7855.5 | |
| All* | Total formula weight | 632469.6 |
