1ZY8

The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005929	cellular_component	cilium
A	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0006508	biological_process	proteolysis
A	0007369	biological_process	gastrulation
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0031410	cellular_component	cytoplasmic vesicle
A	0031514	cellular_component	motile cilium
A	0042391	biological_process	regulation of membrane potential
A	0042995	cellular_component	cell projection
A	0043159	cellular_component	acrosomal matrix
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
A	0048240	biological_process	sperm capacitation
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
A	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
A	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
A	0160167	cellular_component	oxoadipate dehydrogenase complex
A	1902493	cellular_component	acetyltransferase complex
B	0001669	cellular_component	acrosomal vesicle
B	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005929	cellular_component	cilium
B	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0006508	biological_process	proteolysis
B	0007369	biological_process	gastrulation
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0031410	cellular_component	cytoplasmic vesicle
B	0031514	cellular_component	motile cilium
B	0042391	biological_process	regulation of membrane potential
B	0042995	cellular_component	cell projection
B	0043159	cellular_component	acrosomal matrix
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
B	0048240	biological_process	sperm capacitation
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
B	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
B	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
B	0160167	cellular_component	oxoadipate dehydrogenase complex
B	1902493	cellular_component	acetyltransferase complex
C	0001669	cellular_component	acrosomal vesicle
C	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005929	cellular_component	cilium
C	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0006508	biological_process	proteolysis
C	0007369	biological_process	gastrulation
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0031410	cellular_component	cytoplasmic vesicle
C	0031514	cellular_component	motile cilium
C	0042391	biological_process	regulation of membrane potential
C	0042995	cellular_component	cell projection
C	0043159	cellular_component	acrosomal matrix
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
C	0048240	biological_process	sperm capacitation
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
C	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
C	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
C	0160167	cellular_component	oxoadipate dehydrogenase complex
C	1902493	cellular_component	acetyltransferase complex
D	0001669	cellular_component	acrosomal vesicle
D	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005929	cellular_component	cilium
D	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0006508	biological_process	proteolysis
D	0007369	biological_process	gastrulation
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0031410	cellular_component	cytoplasmic vesicle
D	0031514	cellular_component	motile cilium
D	0042391	biological_process	regulation of membrane potential
D	0042995	cellular_component	cell projection
D	0043159	cellular_component	acrosomal matrix
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
D	0048240	biological_process	sperm capacitation
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
D	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
D	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
D	0160167	cellular_component	oxoadipate dehydrogenase complex
D	1902493	cellular_component	acetyltransferase complex
E	0001669	cellular_component	acrosomal vesicle
E	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005929	cellular_component	cilium
E	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0006508	biological_process	proteolysis
E	0007369	biological_process	gastrulation
E	0009083	biological_process	branched-chain amino acid catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0042391	biological_process	regulation of membrane potential
E	0042995	cellular_component	cell projection
E	0043159	cellular_component	acrosomal matrix
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
E	0048240	biological_process	sperm capacitation
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
E	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
E	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
E	0160167	cellular_component	oxoadipate dehydrogenase complex
E	1902493	cellular_component	acetyltransferase complex
F	0001669	cellular_component	acrosomal vesicle
F	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005929	cellular_component	cilium
F	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0006508	biological_process	proteolysis
F	0007369	biological_process	gastrulation
F	0009083	biological_process	branched-chain amino acid catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
F	0031410	cellular_component	cytoplasmic vesicle
F	0031514	cellular_component	motile cilium
F	0042391	biological_process	regulation of membrane potential
F	0042995	cellular_component	cell projection
F	0043159	cellular_component	acrosomal matrix
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0045254	cellular_component	pyruvate dehydrogenase complex
F	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
F	0048240	biological_process	sperm capacitation
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
F	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
F	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
F	0160167	cellular_component	oxoadipate dehydrogenase complex
F	1902493	cellular_component	acetyltransferase complex
G	0001669	cellular_component	acrosomal vesicle
G	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005929	cellular_component	cilium
G	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
G	0006103	biological_process	2-oxoglutarate metabolic process
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0006508	biological_process	proteolysis
G	0007369	biological_process	gastrulation
G	0009083	biological_process	branched-chain amino acid catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
G	0031410	cellular_component	cytoplasmic vesicle
G	0031514	cellular_component	motile cilium
G	0042391	biological_process	regulation of membrane potential
G	0042995	cellular_component	cell projection
G	0043159	cellular_component	acrosomal matrix
G	0045252	cellular_component	oxoglutarate dehydrogenase complex
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
G	0048240	biological_process	sperm capacitation
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
G	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
G	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
G	0160167	cellular_component	oxoadipate dehydrogenase complex
G	1902493	cellular_component	acetyltransferase complex
H	0001669	cellular_component	acrosomal vesicle
H	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005929	cellular_component	cilium
H	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
H	0006103	biological_process	2-oxoglutarate metabolic process
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0006508	biological_process	proteolysis
H	0007369	biological_process	gastrulation
H	0009083	biological_process	branched-chain amino acid catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
H	0031410	cellular_component	cytoplasmic vesicle
H	0031514	cellular_component	motile cilium
H	0042391	biological_process	regulation of membrane potential
H	0042995	cellular_component	cell projection
H	0043159	cellular_component	acrosomal matrix
H	0045252	cellular_component	oxoglutarate dehydrogenase complex
H	0045254	cellular_component	pyruvate dehydrogenase complex
H	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
H	0048240	biological_process	sperm capacitation
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
H	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
H	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
H	0160167	cellular_component	oxoadipate dehydrogenase complex
H	1902493	cellular_component	acetyltransferase complex
I	0001669	cellular_component	acrosomal vesicle
I	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005929	cellular_component	cilium
I	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
I	0006103	biological_process	2-oxoglutarate metabolic process
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0006508	biological_process	proteolysis
I	0007369	biological_process	gastrulation
I	0009083	biological_process	branched-chain amino acid catabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
I	0031410	cellular_component	cytoplasmic vesicle
I	0031514	cellular_component	motile cilium
I	0042391	biological_process	regulation of membrane potential
I	0042995	cellular_component	cell projection
I	0043159	cellular_component	acrosomal matrix
I	0045252	cellular_component	oxoglutarate dehydrogenase complex
I	0045254	cellular_component	pyruvate dehydrogenase complex
I	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
I	0048240	biological_process	sperm capacitation
I	0050660	molecular_function	flavin adenine dinucleotide binding
I	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
I	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
I	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
I	0160167	cellular_component	oxoadipate dehydrogenase complex
I	1902493	cellular_component	acetyltransferase complex
J	0001669	cellular_component	acrosomal vesicle
J	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005929	cellular_component	cilium
J	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
J	0006103	biological_process	2-oxoglutarate metabolic process
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0006508	biological_process	proteolysis
J	0007369	biological_process	gastrulation
J	0009083	biological_process	branched-chain amino acid catabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
J	0031410	cellular_component	cytoplasmic vesicle
J	0031514	cellular_component	motile cilium
J	0042391	biological_process	regulation of membrane potential
J	0042995	cellular_component	cell projection
J	0043159	cellular_component	acrosomal matrix
J	0045252	cellular_component	oxoglutarate dehydrogenase complex
J	0045254	cellular_component	pyruvate dehydrogenase complex
J	0047101	molecular_function	obsolete branched-chain alpha-keto acid dehydrogenase activity
J	0048240	biological_process	sperm capacitation
J	0050660	molecular_function	flavin adenine dinucleotide binding
J	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
J	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
J	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
J	0160167	cellular_component	oxoadipate dehydrogenase complex
J	1902493	cellular_component	acetyltransferase complex
K	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
K	0016746	molecular_function	acyltransferase activity
K	0045254	cellular_component	pyruvate dehydrogenase complex
L	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
L	0016746	molecular_function	acyltransferase activity
L	0045254	cellular_component	pyruvate dehydrogenase complex
M	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
M	0016746	molecular_function	acyltransferase activity
M	0045254	cellular_component	pyruvate dehydrogenase complex
N	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
N	0016746	molecular_function	acyltransferase activity
N	0045254	cellular_component	pyruvate dehydrogenase complex
O	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
O	0016746	molecular_function	acyltransferase activity
O	0045254	cellular_component	pyruvate dehydrogenase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD A 4750

Chain	Residue
A	GLY13
A	CYS45
A	GLY49
A	CYS50
A	LYS54
A	TYR118
A	GLY119
A	ALA147
A	THR148
A	GLY149
A	SER150
A	GLY15
A	ILE189
A	PHE283
A	GLY319
A	ASP320
A	MET326
A	LEU327
A	ALA328
A	HIS329
A	TYR359
A	HOH4752
A	PRO16
A	HOH4763
A	HOH4786
B	HIS452
A	GLY17
A	GLU36
A	LYS37
A	ASN38
A	GLY43
A	THR44

---

site_id	AC2
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD B 4751

Chain	Residue
A	HIS452
B	ILE12
B	GLY13
B	GLY15
B	PRO16
B	GLU36
B	LYS37
B	ASN38
B	GLY43
B	THR44
B	CYS45
B	VAL48
B	GLY49
B	CYS50
B	LYS54
B	TYR118
B	GLY119
B	ALA147
B	THR148
B	GLY149
B	SER150
B	ILE189
B	PHE283
B	GLY319
B	ASP320
B	MET326
B	LEU327
B	ALA328
B	HIS329
B	TYR359
B	HOH4753
B	HOH4764
B	HOH4767
B	HOH4794

---

site_id	AC3
Number of Residues	37
Details	BINDING SITE FOR RESIDUE FAD C 4752

Chain	Residue
C	HOH4759
C	HOH4766
C	HOH4822
D	HIS452
C	ILE12
C	GLY13
C	GLY15
C	PRO16
C	GLY17
C	GLU36
C	LYS37
C	ASN38
C	GLY43
C	THR44
C	CYS45
C	VAL48
C	GLY49
C	CYS50
C	LYS54
C	GLY117
C	TYR118
C	GLY119
C	ALA147
C	THR148
C	GLY149
C	SER150
C	SER168
C	ILE189
C	PHE283
C	GLY319
C	ASP320
C	MET326
C	LEU327
C	ALA328
C	HIS329
C	HOH4753
C	HOH4754

---

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD D 4753

Chain	Residue
C	HIS452
D	ILE12
D	GLY13
D	GLY15
D	PRO16
D	GLU36
D	LYS37
D	ASN38
D	GLY43
D	THR44
D	CYS45
D	GLY49
D	CYS50
D	LYS54
D	GLY119
D	ALA147
D	THR148
D	GLY149
D	SER150
D	ARG280
D	GLY319
D	ASP320
D	MET326
D	LEU327
D	ALA328
D	HIS329
D	TYR359
D	HOH4754
D	HOH4755
D	HOH4767
D	HOH4813

---

site_id	AC5
Number of Residues	37
Details	BINDING SITE FOR RESIDUE FAD E 4754

Chain	Residue
E	ILE12
E	GLY13
E	GLY15
E	PRO16
E	GLY17
E	ILE35
E	GLU36
E	LYS37
E	ASN38
E	GLY43
E	THR44
E	CYS45
E	VAL48
E	GLY49
E	CYS50
E	SER53
E	LYS54
E	TYR118
E	GLY119
E	ALA147
E	THR148
E	GLY149
E	SER150
E	ILE189
E	PHE283
E	GLY319
E	ASP320
E	MET326
E	LEU327
E	ALA328
E	HIS329
E	ALA331
E	TYR359
E	HOH4755
E	HOH4756
E	HOH4767
F	HIS452

---

site_id	AC6
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD F 4755

Chain	Residue
E	HIS452
F	ILE12
F	GLY13
F	GLY15
F	PRO16
F	GLU36
F	LYS37
F	ASN38
F	GLY43
F	THR44
F	CYS45
F	GLY49
F	CYS50
F	LYS54
F	TYR118
F	GLY119
F	ALA147
F	THR148
F	GLY149
F	SER150
F	ILE189
F	PHE283
F	GLY319
F	ASP320
F	MET326
F	LEU327
F	ALA328
F	HIS329
F	TYR359
F	HOH4797

---

site_id	AC7
Number of Residues	35
Details	BINDING SITE FOR RESIDUE FAD G 4756

Chain	Residue
G	ILE12
G	GLY13
G	GLY15
G	PRO16
G	GLY17
G	GLU36
G	LYS37
G	ASN38
G	GLY43
G	THR44
G	CYS45
G	VAL48
G	GLY49
G	CYS50
G	LYS54
G	GLY117
G	TYR118
G	GLY119
G	ALA147
G	THR148
G	GLY149
G	SER150
G	SER168
G	PHE283
G	GLY319
G	ASP320
G	MET326
G	LEU327
G	ALA328
G	TYR359
G	HOH4757
G	HOH4758
G	HOH4784
H	HIS452
H	HOH4783

---

site_id	AC8
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD H 4757

Chain	Residue
G	HIS452
G	HOH4785
H	GLY13
H	GLY15
H	PRO16
H	GLU36
H	LYS37
H	ASN38
H	GLY43
H	THR44
H	CYS45
H	GLY49
H	CYS50
H	LYS54
H	GLY117
H	TYR118
H	GLY119
H	ALA147
H	THR148
H	GLY149
H	SER150
H	SER168
H	ILE189
H	PHE283
H	GLY319
H	ASP320
H	MET326
H	LEU327
H	ALA328
H	HIS329
H	TYR359
H	HOH4758
H	HOH4759
H	HOH4760

---

site_id	AC9
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD I 4758

Chain	Residue
I	GLY13
I	GLY15
I	PRO16
I	GLU36
I	LYS37
I	GLY43
I	THR44
I	CYS45
I	VAL48
I	GLY49
I	CYS50
I	SER53
I	LYS54
I	TYR118
I	GLY119
I	ALA147
I	THR148
I	GLY149
I	SER150
I	SER168
I	ILE189
I	PHE283
I	GLY319
I	ASP320
I	MET326
I	LEU327
I	ALA328
I	HIS329
I	ALA331
I	TYR359
I	HOH4759
I	HOH4761
I	HOH4765
J	HIS452

---

site_id	BC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD J 4759

Chain	Residue
I	HIS452
J	ILE12
J	GLY13
J	PRO16
J	GLU36
J	LYS37
J	ASN38
J	GLY43
J	THR44
J	CYS45
J	VAL48
J	CYS50
J	LYS54
J	TYR118
J	GLY119
J	ALA147
J	THR148
J	GLY149
J	SER150
J	SER168
J	ILE189
J	PHE283
J	GLY319
J	ASP320
J	MET326
J	LEU327
J	ALA328
J	HIS329
J	TYR359
J	HOH4762
J	HOH4785

---

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP

Chain	Residue	Details
A	GLY42-PRO52

---

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GeaVsagDALceIETdKAVvtLdasddGiL

Chain	Residue	Details
K	GLY28-LEU57

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P09624","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	270
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15946682","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Site: {"description":"Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex","evidences":[{"source":"PubMed","id":"20385101","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	50
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	185
Details	Domain: {"description":"Peripheral subunit-binding (PSBD)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01170","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
A	CYS45
A	CYS50
B	HIS452
B	GLU457

---

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
J	CYS45
J	CYS50
I	HIS452
I	GLU457

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
A	HIS452
A	GLU457
B	CYS45
B	CYS50

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
D	HIS452
D	GLU457
C	CYS45
C	CYS50

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
D	CYS45
D	CYS50
C	HIS452
C	GLU457

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
F	HIS452
F	GLU457
E	CYS45
E	CYS50

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
F	CYS45
F	CYS50
E	HIS452
E	GLU457

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
H	HIS452
H	GLU457
G	CYS45
G	CYS50

---

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
H	CYS45
H	CYS50
G	HIS452
G	GLU457

---

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1get

Chain	Residue	Details
J	HIS452
J	GLU457
I	CYS45
I	CYS50

---