1ZS5
Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase PCAF | polymer | 118 | 14052.2 | 1 | UniProt (Q92831) Pfam (PF00439) | Homo sapiens (human) | P300/CBP-associated factor, P/CAF, Histone acetylase PCAF |
| 2 | B (A) | (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE | non-polymer | 199.2 | 1 | Chemie (MIB) |
Sequence modifications
A: 719 - 832 (UniProt: Q92831)
| PDB | External Database | Details |
|---|---|---|
| Gly 715 | - | cloning artifact |
| Ser 716 | - | cloning artifact |
| His 717 | - | cloning artifact |
| Met 718 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14052.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 199.2 | |
| All* | Total formula weight | 14251.5 |
