1ZKK
Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase, H4 lysine-20 specific | polymer | 167 | 18877.3 | 4 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens (human) | Histone H4-K20 methyltransferase, H4-K20-HMTase, SET domain-containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PR-Set7, SET8 |
| 2 | E, F, G, H (E, F, G, H) | Peptide corresponding to residues 15-24 of histone H4 | polymer | 10 | 1284.6 | 4 | UniProt (by SIFTS) (P62805) | ||
| 3 | I, J, K, L (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 1007 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 190 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 186 | - | cloning artifact |
| Ala 187 | - | cloning artifact |
| Met 188 | - | cloning artifact |
| Gly 189 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 80647.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1537.6 | |
| All* | Total formula weight | 82185.2 |
