1ZKK
Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Histone-lysine N-methyltransferase, H4 lysine-20 specific | polymer | 167 | 18877.3 | 4 | UniProt (Q9NQR1) Pfam (PF00856) In PDB | Homo sapiens (human) | Histone H4-K20 methyltransferase, H4-K20-HMTase, SET domain-containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PR-Set7, SET8 |
| 2 | E, F, G, H | Peptide corresponding to residues 15-24 of histone H4 | polymer | 10 | 1284.6 | 4 | UniProt (by SIFTS) (P62805) In PDB | ||
| 3 | A, B, C, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 4 | water | water | 18.0 | 1007 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 190 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 186 | - | cloning artifact |
| Ala 187 | - | cloning artifact |
| Met 188 | - | cloning artifact |
| Gly 189 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 80647.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1537.6 | |
| All* | Total formula weight | 82185.2 |
