1Z5N
Crystal structure of MTA/AdoHcy nucleosidase Glu12Gln mutant complexed with 5-methylthioribose and adenine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | MTA/SAH nucleosidase | polymer | 242 | 25487.1 | 2 | UniProt (P24247) Pfam (PF01048) UniProt (by SIFTS) (P0AF12) | Escherichia coli | P46; 5'-methylthioadenosine nucleosidase; S-adenosylhomocysteine nucleosidase |
| 2 | C, E (A, B) | 5-S-methyl-5-thio-alpha-D-ribofuranose | non-polymer | 180.2 | 2 | Chemie (SR1) | |||
| 3 | D, F (A, B) | ADENINE | non-polymer | 135.1 | 2 | Chemie (ADE) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 232 (UniProt: P24247)
| PDB | External Database | Details |
|---|---|---|
| Phe -10 | - | cloning artifact |
| Gln -9 | - | cloning artifact |
| Gly -8 | - | cloning artifact |
| Ala -7 | - | cloning artifact |
| Met -6 | - | cloning artifact |
| Asp -5 | - | cloning artifact |
| Pro -4 | - | cloning artifact |
| Glu -3 | - | cloning artifact |
| Phe -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| Gln 12 | Glu 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50974.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 630.7 | |
| All* | Total formula weight | 51605.0 |
