1Z5N
Crystal structure of MTA/AdoHcy nucleosidase Glu12Gln mutant complexed with 5-methylthioribose and adenine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | MTA/SAH nucleosidase | polymer | 242 | 25487.1 | 2 | UniProt (P24247) Pfam (PF01048) UniProt (by SIFTS) (P0AF12) | Escherichia coli | P46; 5'-methylthioadenosine nucleosidase; S-adenosylhomocysteine nucleosidase |
| 2 | C, E (A, B) | 5-S-methyl-5-thio-alpha-D-ribofuranose | non-polymer | 180.2 | 2 | Chemie (SR1) PubChem (494) PubChem (439904) PubChem (5289397) PubChem (10313378) PubChem (168359061) PubChem (68214861) PubChem (68263769) PubChem (69403812) PubChem (69405540) PubChem (89333466) PubChem (162367330) PubChem (168360145) PubChem (168361901) PubChem (168365171) PubChem (168369870) PubChem (168370526) PubChem (168373416) | |||
| 3 | D, F (A, B) | ADENINE | non-polymer | 135.1 | 2 | Chemie (ADE) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 232 (UniProt: P24247)
| PDB | External Database | Details |
|---|---|---|
| Phe -10 | - | cloning artifact |
| Gln -9 | - | cloning artifact |
| Gly -8 | - | cloning artifact |
| Ala -7 | - | cloning artifact |
| Met -6 | - | cloning artifact |
| Asp -5 | - | cloning artifact |
| Pro -4 | - | cloning artifact |
| Glu -3 | - | cloning artifact |
| Phe -2 | - | cloning artifact |
| Ser -1 | - | cloning artifact |
| Gln 12 | Glu 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50974.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 630.7 | |
| All* | Total formula weight | 51605.0 |
