1YO8

Structure of the C-terminal domain of human thrombospondin-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	thrombospondin-2	polymer	634	70872.4	1	UniProt (P35442) Pfam (PF12947) Pfam (PF02412) Pfam (PF05735)	Homo sapiens (human)
2	B (B)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62182OO)
3	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D, E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	AA, BA, CA, DA, EA... (A)	CALCIUM ION	non-polymer		40.1	30	Chemie (CA)
6	JA (A)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

A: 551 - 1172 (UniProt: P35442)

PDB	External Database	Details
Ala 548	-	cloning artifact
Asp 549	-	cloning artifact
Pro 550	-	cloning artifact
Mse 675	Met 675	modified residue
Mse 964	Met 964	modified residue
Mse 1041	Met 1041	modified residue
Mse 1134	Met 1134	modified residue
Mse 1159	Met 1159	modified residue
Ala 1173	-	expression tag
Ala 1174	-	expression tag
Gly 1175	-	expression tag
His 1176	-	expression tag
His 1177	-	expression tag
His 1178	-	expression tag
His 1179	-	expression tag
His 1180	-	expression tag
His 1181	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	70872.4
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	32
	Total formula weight	1644.8
All*	Total formula weight	73528.1

*Water molecules are not included.